@inproceedings{6d0bacc9224f4d339e04e9cff3897774,
title = "Modeling the neuroanatomic propagation of ALS in the spinal cord",
abstract = "Recent hypotheses of amyotrophic lateral sclerosis (ALS) progression have posited a point-source origin of motor neuron death with neuroanatomic propagation either contiguously to adjacent regions, or along networks via axonal and synaptic connections. Although the molecular mechanisms of propagation are unknown, one leading hypothesis is a {"}prion-like{"} spread of misfolded and aggregated proteins, including SOD1 and TDP-43. We have developed a mathematical model representing cellular and molecular spread of ALS in the human spinal cord. Our model is based on the stochastic reaction-diffusion master equation approach using a tetrahedral discretized space to capture the complex geometry of the spinal cord. Domain dimension and shape was obtained by reconstructing human spinal cord from high-resolution magnetic resonance (MR) images and known gross and histological neuroanatomy. Our preliminary results qualitatively recapitulate the clinically observed pattern of spread of ALS thorough the spinal cord.",
author = "Brian Drawert and Nimish Thakore and Brian Mitchell and Erik Pioro and John Ravits and Petzold, {Linda R.}",
note = "Publisher Copyright: {\textcopyright} 2017 Author(s).; International Conference of Numerical Analysis and Applied Mathematics 2016, ICNAAM 2016 ; Conference date: 19-09-2016 Through 25-09-2016",
year = "2017",
month = jul,
day = "21",
doi = "10.1063/1.4992150",
language = "English (US)",
series = "AIP Conference Proceedings",
publisher = "American Institute of Physics Inc.",
editor = "Simos, {Theodore E.} and Simos, {Theodore E.} and Charalambos Tsitouras",
booktitle = "International Conference of Numerical Analysis and Applied Mathematics, ICNAAM 2016",
}