Models and approaches to dissect host-symbiont specificity

Mark J. Mandel*

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

31 Scopus citations

Abstract

Animals are symbiotic superorganisms, composed of eukaryotic cells and specific microbial residents that perform essential functions for their host. As humans, we are beginning to appreciate the diversity and function of our own microbiota, but model systems are leading the field in illustrating the molecular mechanisms that allow specific relationships to be recapitulated during each host generation. This review focuses on models in which genetic screens, coupled with genomics, imaging, phylogenetics and population biology, have begun to allow a remarkably detailed investigation into the molecular dissection of the evolution of host specificity in animal symbionts.

Original languageEnglish (US)
Pages (from-to)504-511
Number of pages8
JournalTrends in Microbiology
Volume18
Issue number11
DOIs
StatePublished - Nov 1 2010

ASJC Scopus subject areas

  • Infectious Diseases
  • Microbiology (medical)
  • Microbiology
  • Virology

Fingerprint Dive into the research topics of 'Models and approaches to dissect host-symbiont specificity'. Together they form a unique fingerprint.

Cite this