Models of malignant glioma

Ken Aldape*, Howard Colman, C. David James

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

6 Scopus citations


Malignant gliomas are biologically and clinically aggressive neoplasms with a high mortality rate. Recent therapeutic advances have been modest and incremental at best. An increased understanding of the factors, which promote progressive biologic and clinical behavior, is needed to improve upon current therapeutic modalities. Model systems of glioma, which accurately reflect the biology of the human disease, show promise as a means to accomplish this goal.

Original languageEnglish (US)
Pages (from-to)191-196
Number of pages6
JournalDrug Discovery Today: Disease Models
Issue number2
StatePublished - 2006

ASJC Scopus subject areas

  • Molecular Medicine
  • Drug Discovery


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