Moderate mitral regurgitation in patients undergoing CABG - The MoMIC trial

Per Wierup*, Henrik Egeblad, Sten Lyager Nielsen, Henrik Scherstén, Per Ola Kimblad, Odd Bech-Hansen, Anders Roijer, Folke Nilsson, Patrick M. McCarthy, Denis Bouchard, Jacob Jacobsen, Søren Paaske Johnsen, Steen Hvitfeldt Poulsen, Henning Mølgaard

*Corresponding author for this work

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

Background. The presence of mild to moderate ischemic mitral regurgitation (IMR) marks a significantly reduced long-term survival and increased hospitalizations due to heart-failure. However, it is common practice in many institutions to refrain from repairing the mitral valve in these patients. There are no available conclusive data to support this practice, and thus there is a need for an adequately powered randomized trial. Study design. The Moderate Mitral Regurgitation In Patients Undergoing CABG (MoMIC) trial is the first international multi-center, large-scale study to clarify whether moderate IMR in CABG patients should be corrected. A total of 550 CABG patients with moderate IMR are to be randomized to treatment of either CABG alone or CABG plus mitral valve correction. The primary end point is a composite end point of mortality and rehospitalization for heart failure at five years. The inclusion and randomization of patients started in February 2008. Implication. If correction of moderate IMR in CABG patients proves to be the superior strategy, most patients should be treated accordingly.

Original languageEnglish (US)
Pages (from-to)50-56
Number of pages7
JournalScandinavian Cardiovascular Journal
Volume43
Issue number1
DOIs
StatePublished - Feb 1 2009

Fingerprint

Mitral Valve Insufficiency
Mitral Valve
Heart Failure
Random Allocation
Hospitalization
Survival
Mortality

Keywords

  • Ischemia
  • Mitral
  • Regurgitation
  • Surgery
  • Trial

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

Cite this

Wierup, P., Egeblad, H., Nielsen, S. L., Scherstén, H., Kimblad, P. O., Bech-Hansen, O., ... Mølgaard, H. (2009). Moderate mitral regurgitation in patients undergoing CABG - The MoMIC trial. Scandinavian Cardiovascular Journal, 43(1), 50-56. https://doi.org/10.1080/14017430802430950
Wierup, Per ; Egeblad, Henrik ; Nielsen, Sten Lyager ; Scherstén, Henrik ; Kimblad, Per Ola ; Bech-Hansen, Odd ; Roijer, Anders ; Nilsson, Folke ; McCarthy, Patrick M. ; Bouchard, Denis ; Jacobsen, Jacob ; Johnsen, Søren Paaske ; Poulsen, Steen Hvitfeldt ; Mølgaard, Henning. / Moderate mitral regurgitation in patients undergoing CABG - The MoMIC trial. In: Scandinavian Cardiovascular Journal. 2009 ; Vol. 43, No. 1. pp. 50-56.
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Wierup, P, Egeblad, H, Nielsen, SL, Scherstén, H, Kimblad, PO, Bech-Hansen, O, Roijer, A, Nilsson, F, McCarthy, PM, Bouchard, D, Jacobsen, J, Johnsen, SP, Poulsen, SH & Mølgaard, H 2009, 'Moderate mitral regurgitation in patients undergoing CABG - The MoMIC trial', Scandinavian Cardiovascular Journal, vol. 43, no. 1, pp. 50-56. https://doi.org/10.1080/14017430802430950

Moderate mitral regurgitation in patients undergoing CABG - The MoMIC trial. / Wierup, Per; Egeblad, Henrik; Nielsen, Sten Lyager; Scherstén, Henrik; Kimblad, Per Ola; Bech-Hansen, Odd; Roijer, Anders; Nilsson, Folke; McCarthy, Patrick M.; Bouchard, Denis; Jacobsen, Jacob; Johnsen, Søren Paaske; Poulsen, Steen Hvitfeldt; Mølgaard, Henning.

In: Scandinavian Cardiovascular Journal, Vol. 43, No. 1, 01.02.2009, p. 50-56.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Moderate mitral regurgitation in patients undergoing CABG - The MoMIC trial

AU - Wierup, Per

AU - Egeblad, Henrik

AU - Nielsen, Sten Lyager

AU - Scherstén, Henrik

AU - Kimblad, Per Ola

AU - Bech-Hansen, Odd

AU - Roijer, Anders

AU - Nilsson, Folke

AU - McCarthy, Patrick M.

AU - Bouchard, Denis

AU - Jacobsen, Jacob

AU - Johnsen, Søren Paaske

AU - Poulsen, Steen Hvitfeldt

AU - Mølgaard, Henning

PY - 2009/2/1

Y1 - 2009/2/1

N2 - Background. The presence of mild to moderate ischemic mitral regurgitation (IMR) marks a significantly reduced long-term survival and increased hospitalizations due to heart-failure. However, it is common practice in many institutions to refrain from repairing the mitral valve in these patients. There are no available conclusive data to support this practice, and thus there is a need for an adequately powered randomized trial. Study design. The Moderate Mitral Regurgitation In Patients Undergoing CABG (MoMIC) trial is the first international multi-center, large-scale study to clarify whether moderate IMR in CABG patients should be corrected. A total of 550 CABG patients with moderate IMR are to be randomized to treatment of either CABG alone or CABG plus mitral valve correction. The primary end point is a composite end point of mortality and rehospitalization for heart failure at five years. The inclusion and randomization of patients started in February 2008. Implication. If correction of moderate IMR in CABG patients proves to be the superior strategy, most patients should be treated accordingly.

AB - Background. The presence of mild to moderate ischemic mitral regurgitation (IMR) marks a significantly reduced long-term survival and increased hospitalizations due to heart-failure. However, it is common practice in many institutions to refrain from repairing the mitral valve in these patients. There are no available conclusive data to support this practice, and thus there is a need for an adequately powered randomized trial. Study design. The Moderate Mitral Regurgitation In Patients Undergoing CABG (MoMIC) trial is the first international multi-center, large-scale study to clarify whether moderate IMR in CABG patients should be corrected. A total of 550 CABG patients with moderate IMR are to be randomized to treatment of either CABG alone or CABG plus mitral valve correction. The primary end point is a composite end point of mortality and rehospitalization for heart failure at five years. The inclusion and randomization of patients started in February 2008. Implication. If correction of moderate IMR in CABG patients proves to be the superior strategy, most patients should be treated accordingly.

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KW - Surgery

KW - Trial

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Wierup P, Egeblad H, Nielsen SL, Scherstén H, Kimblad PO, Bech-Hansen O et al. Moderate mitral regurgitation in patients undergoing CABG - The MoMIC trial. Scandinavian Cardiovascular Journal. 2009 Feb 1;43(1):50-56. https://doi.org/10.1080/14017430802430950