Moderate mitral regurgitation in patients undergoing CABG - The MoMIC trial

Per Wierup*, Henrik Egeblad, Sten Lyager Nielsen, Henrik Scherstén, Per Ola Kimblad, Odd Bech-Hansen, Anders Roijer, Folke Nilsson, Patrick M. McCarthy, Denis Bouchard, Jacob Jacobsen, Søren Paaske Johnsen, Steen Hvitfeldt Poulsen, Henning Mølgaard

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

7 Scopus citations


Background. The presence of mild to moderate ischemic mitral regurgitation (IMR) marks a significantly reduced long-term survival and increased hospitalizations due to heart-failure. However, it is common practice in many institutions to refrain from repairing the mitral valve in these patients. There are no available conclusive data to support this practice, and thus there is a need for an adequately powered randomized trial. Study design. The Moderate Mitral Regurgitation In Patients Undergoing CABG (MoMIC) trial is the first international multi-center, large-scale study to clarify whether moderate IMR in CABG patients should be corrected. A total of 550 CABG patients with moderate IMR are to be randomized to treatment of either CABG alone or CABG plus mitral valve correction. The primary end point is a composite end point of mortality and rehospitalization for heart failure at five years. The inclusion and randomization of patients started in February 2008. Implication. If correction of moderate IMR in CABG patients proves to be the superior strategy, most patients should be treated accordingly.

Original languageEnglish (US)
Pages (from-to)50-56
Number of pages7
JournalScandinavian Cardiovascular Journal
Issue number1
StatePublished - Feb 1 2009


  • Ischemia
  • Mitral
  • Regurgitation
  • Surgery
  • Trial

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine


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