Modification of fibrous poly(L-lactic acid) scaffolds with self-assembling triblock molecules

John C. Stendahl, Leiming Li, Randal C. Claussen, Samuel I. Stupp*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

23 Scopus citations


Molecular self-assembly offers an effective method to modify the surface properties of common biomaterials by presenting biologically relevant chemistry in a controlled, ordered fashion. This work reports on self-assembling triblock molecules containing rigid cholesteryl segments followed by flexible oligomers of L-(lactic acid) and second generation L-lysine dendrons. Second harmonic generation and small angle X-ray scattering indicate these molecules self-assemble into multilayer polar structures when cast from ethyl acetate solutions and segregate into polar polydomains when annealed. These self-assembled layers significantly improve water wettability when coated onto poly(L-lactic acid) fibers. Scaffolds formed from fibers modified by self-assembly enhance adhesion of 3T3 mouse calvaria cells and produce greater population growth rates. These results demonstrate the use of self-assembly to present biologically relevant chemistry on surfaces of biomaterials. Applications of this technology include the modification of substrates for cell culture, tissue engineering, and cell transplantation.

Original languageEnglish (US)
Pages (from-to)5847-5856
Number of pages10
Issue number27
StatePublished - Dec 2004


  • Cell adhesion
  • Polylactic acid
  • Scaffold
  • Self-assembly
  • Surface modification

ASJC Scopus subject areas

  • Bioengineering
  • Ceramics and Composites
  • Biophysics
  • Biomaterials
  • Mechanics of Materials

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