Modified prosthetic vascular conduits

Muneera R. Kapadia, Daniel A. Popowich, Melina R. Kibbe

Research output: Contribution to journalReview article

88 Scopus citations

Abstract

Atherosclerosis in the form of peripheral arterial disease results in significant morbidity. Surgical treatment options for peripheral arterial disease include angioplasty, endarterectomy, and bypass grafting. For bypass grafting, vein remains the conduit of choice; however, poor quality and limited availability have led to the use of prosthetic materials. Unfortunately, because of a lack of endothelium and compliance mismatch, neointimal hyperplasia develops aggressively, resulting in high failure rates. To improve graft patency, investigators have developed surgical, chemical, and biological graft modifications. This review describes common prosthetic materials, as well as approaches currently in use and under investigation to modify and improve prosthetic conduits for bypass grafting in an effort to improve graft patency rates.

Original languageEnglish (US)
Pages (from-to)1873-1882
Number of pages10
JournalCirculation
Volume117
Issue number14
DOIs
StatePublished - Apr 1 2008

Keywords

  • Atherosclerosis
  • Bypass
  • Peripheral vascular disease
  • Restenosis
  • Revascularization

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine
  • Physiology (medical)

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    Kapadia, M. R., Popowich, D. A., & Kibbe, M. R. (2008). Modified prosthetic vascular conduits. Circulation, 117(14), 1873-1882. https://doi.org/10.1161/CIRCULATIONAHA.107.714170