ModuLand plug-in for Cytoscape: Determination of hierarchical layers of overlapping network modules and community centrality

Máté Szalay-Beko, Robin Palotai, Balázs Szappanos, István A. Kovács, Balázs Papp, Péter Csermely*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

76 Scopus citations

Abstract

Summary: The ModuLand plug-in provides Cytoscape users an algorithm for determining extensively overlapping network modules. Moreover, it identifies several hierarchical layers of modules, where meta-nodes of the higher hierarchical layer represent modules of the lower layer. The tool assigns module cores, which predict the function of the whole module, and determines key nodes bridging two or multiple modules. The plug-in has a detailed JAVA-based graphical interface with various colouring options. The ModuLand tool can run on Windows, Linux or Mac OS. We demonstrate its use on protein structure and metabolic networks.

Original languageEnglish (US)
Article numberbts352
Pages (from-to)2202-2204
Number of pages3
JournalBioinformatics
Volume28
Issue number16
DOIs
StatePublished - Aug 2012

ASJC Scopus subject areas

  • Statistics and Probability
  • Biochemistry
  • Molecular Biology
  • Computer Science Applications
  • Computational Theory and Mathematics
  • Computational Mathematics

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