Abstract
Summary: The ModuLand plug-in provides Cytoscape users an algorithm for determining extensively overlapping network modules. Moreover, it identifies several hierarchical layers of modules, where meta-nodes of the higher hierarchical layer represent modules of the lower layer. The tool assigns module cores, which predict the function of the whole module, and determines key nodes bridging two or multiple modules. The plug-in has a detailed JAVA-based graphical interface with various colouring options. The ModuLand tool can run on Windows, Linux or Mac OS. We demonstrate its use on protein structure and metabolic networks.
Original language | English (US) |
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Article number | bts352 |
Pages (from-to) | 2202-2204 |
Number of pages | 3 |
Journal | Bioinformatics |
Volume | 28 |
Issue number | 16 |
DOIs | |
State | Published - Aug 2012 |
Funding
Funding: EU [FP6-518230, TÁMOP-4.2.2/B-10/1-2010-0013 and FP7-264780]; Hungarian Scientific Research Fund [OTKA K-83314 and PD-75261]; International Human Frontiers Science Program Organization (BP); Momentum Program of the Hungarian Academy of Sciences (BP); and residence at the Rockefeller Foundation Bellagio Center (PC).
ASJC Scopus subject areas
- Computational Mathematics
- Molecular Biology
- Biochemistry
- Statistics and Probability
- Computer Science Applications
- Computational Theory and Mathematics