TY - JOUR
T1 - Modular and Chemically Responsive Oligonucleotide "bonds" in Nanoparticle Superlattices
AU - Barnaby, Stacey N.
AU - Thaner, Ryan V.
AU - Ross, Michael B.
AU - Brown, Keith A.
AU - Schatz, George C.
AU - Mirkin, Chad A.
N1 - Publisher Copyright:
© 2015 American Chemical Society.
PY - 2015/10/28
Y1 - 2015/10/28
N2 - Chemical bonds are a key determinant of the structure and properties of a material. Thus, rationally designing arbitrary materials requires complete control over the bond. While atomic bonding is dictated by the identity of the atoms, nanoparticle superlattice engineering, where nanoparticle "atoms" are held together by DNA "bonds", offers a route to design crystal lattices in a way that nature cannot: through altering the oligonucleotide bond. Herein, the use of RNA, as opposed to DNA, is explored by synthesizing superlattices in which nanoparticles are bonded by DNA/DNA, RNA/RNA, and DNA/RNA duplexes. By moving beyond nanoparticle superlattices assembled only with DNA, a new degree of freedom is introduced, providing programmed responsiveness to enzymes and greater bond versatility. Therefore, the oligonucleotide bond can have programmable function beyond dictating the structure of the material and moves nanoparticle superlattices closer to naturally occurring biomaterials, where the line between structural and functional elements is blurred.
AB - Chemical bonds are a key determinant of the structure and properties of a material. Thus, rationally designing arbitrary materials requires complete control over the bond. While atomic bonding is dictated by the identity of the atoms, nanoparticle superlattice engineering, where nanoparticle "atoms" are held together by DNA "bonds", offers a route to design crystal lattices in a way that nature cannot: through altering the oligonucleotide bond. Herein, the use of RNA, as opposed to DNA, is explored by synthesizing superlattices in which nanoparticles are bonded by DNA/DNA, RNA/RNA, and DNA/RNA duplexes. By moving beyond nanoparticle superlattices assembled only with DNA, a new degree of freedom is introduced, providing programmed responsiveness to enzymes and greater bond versatility. Therefore, the oligonucleotide bond can have programmable function beyond dictating the structure of the material and moves nanoparticle superlattices closer to naturally occurring biomaterials, where the line between structural and functional elements is blurred.
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U2 - 10.1021/jacs.5b07908
DO - 10.1021/jacs.5b07908
M3 - Article
C2 - 26465067
AN - SCOPUS:84945948849
VL - 137
SP - 13566
EP - 13571
JO - Journal of the American Chemical Society
JF - Journal of the American Chemical Society
SN - 0002-7863
IS - 42
ER -