Modular evolution of phosphorylation-based signalling systems

Jing Jin*, Tony Pawson

*Corresponding author for this work

Research output: Contribution to journalReview article

73 Citations (Scopus)

Abstract

Phosphorylation sites are formed by protein kinases ('writers'), frequently exert their effects following recognition by phospho-binding proteins ('readers') and are removed by protein phosphatases ('erasers'). This writer-reader-eraser toolkit allows phosphorylation events to control a broad range of regulatory processes, and has been pivotal in the evolution of new functions required for the development of multi-cellular animals. The proteins that comprise this system of protein kinases, phospho-binding targets and phosphatases are typically modular in organization, in the sense that they are composed of multiple globular domains and smaller peptide motifs with binding or catalytic properties. The linkage of these binding and catalytic modules in new ways through genetic recombination, and the selection of particular domain combinations, has promoted the evolution of novel, biologically useful processes. Conversely, the joining of domains in aberrant combinations can subvert cell signalling and be causative in diseases such as cancer. Major inventions such as phosphotyrosine (pTyr)-mediated signalling that flourished in the first multi-cellular animals and their immediate predecessors resulted from stepwise evolutionary progression. This involved changes in the binding properties of interaction domains such as SH2 and their linkage to new domain types, and alterations in the catalytic specificities of kinases and phosphatases. This review will focus on the modular aspects of signalling networks and the mechanism by which they may have evolved.

Original languageEnglish (US)
Pages (from-to)2540-2555
Number of pages16
JournalPhilosophical Transactions of the Royal Society B: Biological Sciences
Volume367
Issue number1602
DOIs
StatePublished - Jan 1 2012

Fingerprint

Phosphorylation
Phosphoric Monoester Hydrolases
protein kinases
Protein Kinases
linkage (genetics)
phosphorylation
Animals
Cell signaling
genetic recombination
Phosphotyrosine
binding properties
Phosphoprotein Phosphatases
Patents and inventions
Joining
Genetic Recombination
binding proteins
animals
Carrier Proteins
phosphotransferases (kinases)
Phosphotransferases

Keywords

  • Coevolution
  • Domain linkage
  • Interaction domain
  • Phosphorylation
  • Protein kinase
  • Protein phosphatase

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Agricultural and Biological Sciences(all)

Cite this

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abstract = "Phosphorylation sites are formed by protein kinases ('writers'), frequently exert their effects following recognition by phospho-binding proteins ('readers') and are removed by protein phosphatases ('erasers'). This writer-reader-eraser toolkit allows phosphorylation events to control a broad range of regulatory processes, and has been pivotal in the evolution of new functions required for the development of multi-cellular animals. The proteins that comprise this system of protein kinases, phospho-binding targets and phosphatases are typically modular in organization, in the sense that they are composed of multiple globular domains and smaller peptide motifs with binding or catalytic properties. The linkage of these binding and catalytic modules in new ways through genetic recombination, and the selection of particular domain combinations, has promoted the evolution of novel, biologically useful processes. Conversely, the joining of domains in aberrant combinations can subvert cell signalling and be causative in diseases such as cancer. Major inventions such as phosphotyrosine (pTyr)-mediated signalling that flourished in the first multi-cellular animals and their immediate predecessors resulted from stepwise evolutionary progression. This involved changes in the binding properties of interaction domains such as SH2 and their linkage to new domain types, and alterations in the catalytic specificities of kinases and phosphatases. This review will focus on the modular aspects of signalling networks and the mechanism by which they may have evolved.",
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Modular evolution of phosphorylation-based signalling systems. / Jin, Jing; Pawson, Tony.

In: Philosophical Transactions of the Royal Society B: Biological Sciences, Vol. 367, No. 1602, 01.01.2012, p. 2540-2555.

Research output: Contribution to journalReview article

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