Modular polymer-caged nanobins as a theranostic platform with enhanced magnetic resonance relaxivity and pH-responsive drug release

Sang Min Lee, Ying Song, Bong Jin Hong, Keith W. MacRenaris, Daniel J. Mastarone, Thomas V. O'Halloran, Thomas J. Meade, Sonbinh T. Nguyen

Research output: Contribution to journalArticlepeer-review

48 Scopus citations

Abstract

Polymer-caged nanobins (PCNs) that can undergo Cu(I)-catalyzed click reactions enable the combination of GdIII magnetic resonance imaging (MRI) contrast agents and an anticancer drug (gemcitabine, GMC) into a single theranostic platform (see picture). The resulting gadolinium(III)-conjugated, GMC-loaded PCNs (GdIII-PCNGMC) exhibit a significantly superior performance in r1 relaxivity, drug uptake, and pH-sensitive drug release.

Original languageEnglish (US)
Pages (from-to)9960-9964
Number of pages5
JournalAngewandte Chemie - International Edition
Volume49
Issue number51
DOIs
StatePublished - Dec 17 2010

Keywords

  • antitumor agents
  • drug delivery
  • gadolinium
  • liposomes
  • magnetic resonance imaging

ASJC Scopus subject areas

  • Catalysis
  • Chemistry(all)

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