Modular polymer-caged nanobins as a theranostic platform with enhanced magnetic resonance relaxivity and pH-responsive drug release

Sang Min Lee; Ying Song; Bong Jin Hong; Keith W. MacRenaris; Daniel J. Mastarone; Thomas V. O'Halloran; Thomas J. Meade; Sonbinh T. Nguyen

doi:10.1002/anie.201004867

Modular polymer-caged nanobins as a theranostic platform with enhanced magnetic resonance relaxivity and pH-responsive drug release

Sang Min Lee, Ying Song, Bong Jin Hong, Keith W. MacRenaris, Daniel J. Mastarone, Thomas V. O'Halloran, Thomas J. Meade, Sonbinh T. Nguyen

Research output: Contribution to journal › Article › peer-review

54 Scopus citations

Abstract

Polymer-caged nanobins (PCNs) that can undergo Cu(I)-catalyzed click reactions enable the combination of Gd^III magnetic resonance imaging (MRI) contrast agents and an anticancer drug (gemcitabine, GMC) into a single theranostic platform (see picture). The resulting gadolinium(III)-conjugated, GMC-loaded PCNs (Gd^III-PCN_GMC) exhibit a significantly superior performance in r₁ relaxivity, drug uptake, and pH-sensitive drug release.

Original language	English (US)
Pages (from-to)	9960-9964
Number of pages	5
Journal	Angewandte Chemie - International Edition
Volume	49
Issue number	51
DOIs	https://doi.org/10.1002/anie.201004867
State	Published - Dec 17 2010

Keywords

antitumor agents
drug delivery
gadolinium
liposomes
magnetic resonance imaging

ASJC Scopus subject areas

General Chemistry
Catalysis

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10.1002/anie.201004867

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abstract = "Polymer-caged nanobins (PCNs) that can undergo Cu(I)-catalyzed click reactions enable the combination of GdIII magnetic resonance imaging (MRI) contrast agents and an anticancer drug (gemcitabine, GMC) into a single theranostic platform (see picture). The resulting gadolinium(III)-conjugated, GMC-loaded PCNs (GdIII-PCNGMC) exhibit a significantly superior performance in r1 relaxivity, drug uptake, and pH-sensitive drug release.",

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T1 - Modular polymer-caged nanobins as a theranostic platform with enhanced magnetic resonance relaxivity and pH-responsive drug release

AU - Lee, Sang Min

AU - Song, Ying

AU - Hong, Bong Jin

AU - MacRenaris, Keith W.

AU - Mastarone, Daniel J.

AU - O'Halloran, Thomas V.

AU - Meade, Thomas J.

AU - Nguyen, Sonbinh T.

PY - 2010/12/17

Y1 - 2010/12/17

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AB - Polymer-caged nanobins (PCNs) that can undergo Cu(I)-catalyzed click reactions enable the combination of GdIII magnetic resonance imaging (MRI) contrast agents and an anticancer drug (gemcitabine, GMC) into a single theranostic platform (see picture). The resulting gadolinium(III)-conjugated, GMC-loaded PCNs (GdIII-PCNGMC) exhibit a significantly superior performance in r1 relaxivity, drug uptake, and pH-sensitive drug release.

KW - antitumor agents

KW - drug delivery

KW - gadolinium

KW - liposomes

KW - magnetic resonance imaging

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Modular polymer-caged nanobins as a theranostic platform with enhanced magnetic resonance relaxivity and pH-responsive drug release

Abstract

Keywords

ASJC Scopus subject areas

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