Modulating expanded polytetrafluoroethylene vascular graft host response via citric acid-based biodegradable elastomers

Jian Yang*, Delara Motlagh, Josephine B. Allen, Antonio R. Webb, Melina R. Kibbe, Oliver Aalami, Muneera Kapadia, Timothy J. Carroll, Guillermo A. Ameer

*Corresponding author for this work

Research output: Contribution to journalArticle

75 Scopus citations

Abstract

The use of synthetic biodegradable polymers as a means to tissue-engineer a functional endothelium on expanded polytetrafluoroethylene (ePTFE) grafts was investigated. It was shown that the biodegradable elastomer poly(1,8-octanediol citrate (POC) can confer improved biocompatibility characteristics on ePTFE vascular grafts without affecting graft compliance. It was observed that synthesis of POC can be conducted under relatively low temperatures without vacuum and catalysts. It was observed that POC modification can significantly improve the hemocompatibility and acute inflammatory response of ePTFE grafts implemented in a porcine iliac artery ePTFE bypass model. It was found that the POC interface confers hydrophilicity, reduces thrombogenicity, and reduces in vivo macrophage infiltration into the ePTFE grafts.

Original languageEnglish (US)
Pages (from-to)1493-1498
Number of pages6
JournalAdvanced Materials
Volume18
Issue number12
DOIs
StatePublished - Jun 19 2006

ASJC Scopus subject areas

  • Materials Science(all)
  • Mechanics of Materials
  • Mechanical Engineering

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    Yang, J., Motlagh, D., Allen, J. B., Webb, A. R., Kibbe, M. R., Aalami, O., Kapadia, M., Carroll, T. J., & Ameer, G. A. (2006). Modulating expanded polytetrafluoroethylene vascular graft host response via citric acid-based biodegradable elastomers. Advanced Materials, 18(12), 1493-1498. https://doi.org/10.1002/adma.200600230