Modulating intestinal immune responses by lipoteichoic acid-deficient Lactobacillus acidophilus

Mohammad W. Khan, Mojgan Zadeh, Praveen Bere, Elias Gounaris, Jennifer Owen, Todd Klaenhammer, Mansour Mohamadzadeh*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

19 Scopus citations


Aim: To investigate the mechanism(s) by which the intestinal commensal microbe Lactobacillus acidophilus can affect host immunity, we studied the role of a component of the cell wall, lipoteichoic acid, in colitis. Materials & methods: Colitis was induced by the intraperitoneal injection of pathogenic CD4 +CD25 -CD45RB hi T cells into Rag1 -/- mice. The parental strain, NCK56, or the lipoteichoic acid-deficient strain, NCK2025, was then administered orally. Fluorescent microscopy was employed to examine resulting cell populations and their cytokine production in the colon. Results: NCK2025 enhanced IL-10 production by dendritic cells and macrophages. Increased numbers of regulatory dendritic cells coincided with the induction of activated FoxP3 + Tregs. Conclusion: These results suggest that the oral administration of the genetically modified strain NCK2025 may be an effective immunotherapeutic approach that reprograms the immune response in colonic inflammatory conditions.

Original languageEnglish (US)
Pages (from-to)151-161
Number of pages11
Issue number2
StatePublished - Feb 2012


  • Lactobacillus acidophilus
  • Tregs
  • dendritic cells
  • macrophages
  • regulatory innate immune cells

ASJC Scopus subject areas

  • Oncology
  • Immunology and Allergy
  • Immunology


Dive into the research topics of 'Modulating intestinal immune responses by lipoteichoic acid-deficient Lactobacillus acidophilus'. Together they form a unique fingerprint.

Cite this