Modulating the activity of neural crest regulatory factors

Kimberly M. Taylor; Carole LaBonne

doi:10.1016/j.gde.2007.05.012

Modulating the activity of neural crest regulatory factors

Kimberly M. Taylor^*, Carole LaBonne

^*Corresponding author for this work

Molecular Biosciences

Research output: Contribution to journal › Review article › peer-review

28 Scopus citations

Abstract

Substantial progress has been made in defining the regulatory factors involved in generating multipotent neural crest cells at the neural plate border of vertebrate embryos, controlling the onset of their migratory behavior, and directing their differentiation into one of a diverse array of derivatives. Growing evidence suggests that these factors function as a complex network, in some cases displaying overlapping functions and cross-regulatory interactions. Mechanisms are emerging for how some of these regulatory components are controlled post-translationally and the extent to which their activities are conserved across species.

Original language	English (US)
Pages (from-to)	326-331
Number of pages	6
Journal	Current Opinion in Genetics and Development
Volume	17
Issue number	4
DOIs	https://doi.org/10.1016/j.gde.2007.05.012
State	Published - Aug 2007

Funding

We apologize to colleagues whose work could not be cited due to space constraints, and acknowledge members of the lab for helpful discussions. KT is supported by F31DC007790. This work was supported by RO1CA11405, ACS RSG107296, and a Scholar Award from the GM Cancer Research Foundation to CL.

ASJC Scopus subject areas

Genetics
Developmental Biology

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10.1016/j.gde.2007.05.012

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abstract = "Substantial progress has been made in defining the regulatory factors involved in generating multipotent neural crest cells at the neural plate border of vertebrate embryos, controlling the onset of their migratory behavior, and directing their differentiation into one of a diverse array of derivatives. Growing evidence suggests that these factors function as a complex network, in some cases displaying overlapping functions and cross-regulatory interactions. Mechanisms are emerging for how some of these regulatory components are controlled post-translationally and the extent to which their activities are conserved across species.",

author = "Taylor, {Kimberly M.} and Carole LaBonne",

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N2 - Substantial progress has been made in defining the regulatory factors involved in generating multipotent neural crest cells at the neural plate border of vertebrate embryos, controlling the onset of their migratory behavior, and directing their differentiation into one of a diverse array of derivatives. Growing evidence suggests that these factors function as a complex network, in some cases displaying overlapping functions and cross-regulatory interactions. Mechanisms are emerging for how some of these regulatory components are controlled post-translationally and the extent to which their activities are conserved across species.

AB - Substantial progress has been made in defining the regulatory factors involved in generating multipotent neural crest cells at the neural plate border of vertebrate embryos, controlling the onset of their migratory behavior, and directing their differentiation into one of a diverse array of derivatives. Growing evidence suggests that these factors function as a complex network, in some cases displaying overlapping functions and cross-regulatory interactions. Mechanisms are emerging for how some of these regulatory components are controlled post-translationally and the extent to which their activities are conserved across species.

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Modulating the activity of neural crest regulatory factors

Abstract

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