Modulation of CXCR4, CXCL12, and tumor cell invasion potential in vitro by phytochemicals

Oliver Hankinson*, Erin L. Hsu, Natalie Chen, Aya Westbrook, Feng Wang, Ruixue Zhang, Robert T. Taylor

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

20 Scopus citations

Abstract

CXCR4 is a chemokine receptor frequently overexpressed on primary tumor cells. Organs to which these cancers metastasize secrete CXCL12, the unique ligand for CXCR4, which stimulates invasion and metastasis to these sites. Similar to our previous work with the chemoprotective phytochemical, 3, 3 ′ -diindolylmethane (DIM), we show here that genistein also downregulates CXCR4 and CXCL12 and subsequently lowers the migratory and invasive potentials of breast and ovarian cancer cells. Moreover, genistein and DIM elicit a significantly greater cumulative effect in lowering CXCR4 and CXCL12 levels than either compound alone. Our data suggest a novel mechanism for the protective effects of phytochemicals against cancer progression and indicate that in combination, these compounds may prove even more efficacious.

Original languageEnglish (US)
Article number491985
JournalJournal of Oncology
DOIs
StatePublished - 2009

ASJC Scopus subject areas

  • Oncology

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