Modulation of dopamine metabolism in the retina via dopamine D2 receptors

Maria Hadjiconstantinou, Dimitrij Krajnc, Zvani Rossetti, Norton H. Neff*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

8 Scopus citations


When rats are placed in a lighted environment from the dark retinal DOPAC increases. There is no significant change of retinal dopamine (DA) under either lighting condition. Blockade of aromatic l-amino acid decarboxylase results in a more rapid accumulation of DOPA in the retina of animals in the light than in the dark implying that DA synthesis and metabolism are more rapid in the light than in the dark. Retinal DOPAC increases in the dark and in the light when rats are treated with the DA D2 antagonists sulpiride and spiperone. Treatment with the D2 agonist, quinpirole, lowers the content of DA in the retina of rats kept in the dark or exposed to light. D1 receptor drugs induce only limited changes in DA metabolism. We conclude that D2 receptors play a principal role for modulating DA synthesis and metabolism in the rat retina.

Original languageEnglish (US)
Pages (from-to)20-23
Number of pages4
JournalBrain research
Issue number1
StatePublished - Nov 12 1990


  • D receptor
  • Dopamine
  • Environmental lighting
  • Metabolism
  • Retina
  • Synthesis

ASJC Scopus subject areas

  • Neuroscience(all)
  • Molecular Biology
  • Clinical Neurology
  • Developmental Biology


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