Modulation of epithelial differentiation by the E6 and E7 oncoproteins of human papillomaviruses

Paolo Monini, Laimonis A Laimins*

*Corresponding author for this work

Research output: Contribution to journalArticle

1 Scopus citations

Abstract

Human papillomaviruses (HPVs) infect squamous epithelial cells of the genital tract and induce a variety of hyperproliferative lesions, including carcinomas. The vegetative viral life cycle is linked closely to epithelial differentiation, with virion production occurring only in highly differentiated suprabasal cells. We have used organotypic cultures to study the effects of HPV gene products on epithelial differentiation. Although E6 and E7 gene products immortalize normal human keratinocytes efficiently in culture, additional cellular mutations are required to induce a complete loss of differentiation capability. These results are consistent with a multistep process in the development of HPV‐associated anogenital malignancies in vivo. © 1995 Wiley‐Liss, Inc.

Original languageEnglish (US)
Pages (from-to)377-382
Number of pages6
JournalRadiation Oncology Investigations
Volume3
Issue number6
DOIs
StatePublished - Jan 1 1995

Keywords

  • keratinocytes
  • organotypic cultures
  • rafts
  • viral transformation

ASJC Scopus subject areas

  • Radiation
  • Radiological and Ultrasound Technology
  • Oncology
  • Radiology Nuclear Medicine and imaging

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