Modulation of humoral immune response by central administration of leucine-enkephalin: Effects of μ, ∂ and κ opioid receptor antagonists

Jelena Radulović*, Zorica Mančev, Stanislava Stanojević, Tatjana Vasiljević, Vesna Kovačević-Jovanović, Gordana Pešić

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

23 Scopus citations

Abstract

The effect of leucine-enkephalin (Leu-Enk) on primary humoral immune response was investigated following intracerebroventricular (i.c.v.) administration of the peptide in the rat. Leu-Enk stimulated plaque-forming cell (PFC) response in rats i.c.v. injected with 0.1 and 1 μg/kg, whereas doses of 20 and 50 μg/kg exerted immunosuppressive effects. I.c.v. treatment of rats with ∂ opioid receptor antagonist ICI 174864 and κ opioid receptor antagonist nor-binaltorphimine (nor-BNI) blocked stimulation and suppression of PFC response induced by Leu-Enk, respectively. The μ opioid receptor antagonist β-funaltrexamine (β-FNA) reversed both immunomodulatory effects produced by Leu-Enk. Since β-FNA alone had no effect on PFC response (unlike ICI 174 864 and nor-BNI), these data showed that central effects of Leu-Enk on PFC response were mediated by brain μ opioid receptors, and suggested a possible involvement of ∂ and κ opioid receptors.

Original languageEnglish (US)
Pages (from-to)155-161
Number of pages7
JournalJournal of Neuroimmunology
Volume65
Issue number2
DOIs
StatePublished - Apr 1996

Keywords

  • Central nervous system
  • Leucine-enkephalin
  • Plaque-forming cell response
  • κ opioid receptors
  • μ opioid receptors
  • ∂ opioid receptors

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology
  • Neurology
  • Clinical Neurology

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