Modulation of hypothalamic protein kinase C activity by α-glyceryl-phosphoryl-O-serine (GPS) in aged rats

G. Aleppo; M. A. Sortino; U. Scapagnini; P. L. Canonico

Modulation of hypothalamic protein kinase C activity by α-glyceryl-phosphoryl-O-serine (GPS) in aged rats

G. Aleppo, M. A. Sortino, U. Scapagnini, P. L. Canonico^*

^*Corresponding author for this work

Medicine, Endocrinology Division

Research output: Contribution to journal › Article › peer-review

Abstract

A single treatment with GPS increased protein kinase C (PKC) activity in the particulate fraction of hypothalamic slices without affecting cytosolic PKC. By contrast, a 30-day treatment with 100 mg/kg/die GPS did not modify PKC activity in young animals while partially restoring the reduced cytosolic PKC activity observed in aged rats.

Original language	English (US)
Pages (from-to)	41-46
Number of pages	6
Journal	Neuroendocrinology Letters
Volume	16
Issue number	1
State	Published - 1994

ASJC Scopus subject areas

Endocrinology, Diabetes and Metabolism
Endocrinology
Neurology
Endocrine and Autonomic Systems
Clinical Neurology
Psychiatry and Mental health

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Cite this

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title = "Modulation of hypothalamic protein kinase C activity by α-glyceryl-phosphoryl-O-serine (GPS) in aged rats",

abstract = "A single treatment with GPS increased protein kinase C (PKC) activity in the particulate fraction of hypothalamic slices without affecting cytosolic PKC. By contrast, a 30-day treatment with 100 mg/kg/die GPS did not modify PKC activity in young animals while partially restoring the reduced cytosolic PKC activity observed in aged rats.",

author = "G. Aleppo and Sortino, {M. A.} and U. Scapagnini and Canonico, {P. L.}",

year = "1994",

language = "English (US)",

volume = "16",

pages = "41--46",

journal = "Neuroendocrinology Letters",

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publisher = "Maghira and Maas Publications",

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T1 - Modulation of hypothalamic protein kinase C activity by α-glyceryl-phosphoryl-O-serine (GPS) in aged rats

AU - Aleppo, G.

AU - Sortino, M. A.

AU - Scapagnini, U.

AU - Canonico, P. L.

PY - 1994

Y1 - 1994

N2 - A single treatment with GPS increased protein kinase C (PKC) activity in the particulate fraction of hypothalamic slices without affecting cytosolic PKC. By contrast, a 30-day treatment with 100 mg/kg/die GPS did not modify PKC activity in young animals while partially restoring the reduced cytosolic PKC activity observed in aged rats.

AB - A single treatment with GPS increased protein kinase C (PKC) activity in the particulate fraction of hypothalamic slices without affecting cytosolic PKC. By contrast, a 30-day treatment with 100 mg/kg/die GPS did not modify PKC activity in young animals while partially restoring the reduced cytosolic PKC activity observed in aged rats.

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UR - http://www.scopus.com/inward/citedby.url?scp=0028009176&partnerID=8YFLogxK

M3 - Article

AN - SCOPUS:0028009176

SN - 0172-780X

VL - 16

SP - 41

EP - 46

JO - Neuroendocrinology Letters

JF - Neuroendocrinology Letters

IS - 1

ER -

Modulation of hypothalamic protein kinase C activity by α-glyceryl-phosphoryl-O-serine (GPS) in aged rats

Abstract

ASJC Scopus subject areas

UN SDGs

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