Modulation of hypothalamic protein kinase C activity by α-glyceryl-phosphoryl-O-serine (GPS) in aged rats

G. Aleppo, M. A. Sortino, U. Scapagnini, P. L. Canonico*

*Corresponding author for this work

Research output: Contribution to journalArticle

Abstract

A single treatment with GPS increased protein kinase C (PKC) activity in the particulate fraction of hypothalamic slices without affecting cytosolic PKC. By contrast, a 30-day treatment with 100 mg/kg/die GPS did not modify PKC activity in young animals while partially restoring the reduced cytosolic PKC activity observed in aged rats.

Original languageEnglish (US)
Pages (from-to)41-46
Number of pages6
JournalNeuroendocrinology Letters
Volume16
Issue number1
StatePublished - Jan 1 1994

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism
  • Endocrinology
  • Neurology
  • Endocrine and Autonomic Systems
  • Clinical Neurology
  • Psychiatry and Mental health

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