Modulation of neurophysiological auditory processing measures by bilateral transcranial direct current stimulation in schizophrenia

Walter Dunn; Yuri Rassovsky; Jonathan K. Wynn; Allan D. Wu; Marco Iacoboni; Gerhard Hellemann; Michael F. Green

doi:10.1016/j.schres.2016.04.021

Modulation of neurophysiological auditory processing measures by bilateral transcranial direct current stimulation in schizophrenia

Walter Dunn^*, Yuri Rassovsky, Jonathan K. Wynn, Allan D. Wu, Marco Iacoboni, Gerhard Hellemann, Michael F. Green

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

14 Scopus citations

Abstract

This study used bilateral transcranial direct current stimulation (tDCS) to target neural generators of auditory Mismatch Negativity (MMN) and oddball P300 in schizophrenia patients. tDCS was applied to the pre-frontal cortex in a parallel between-group design. There was a significant main effect of stimulation resulting in modulation of MMN amplitude. This effect was mainly driven by a non-significant, but large, effect-size decrease in MMN amplitude with anodal stimulation. This is the first study to demonstrate that tDCS is able to engage and modulate an EEG-based auditory processing measure in schizophrenia.

Original language	English (US)
Pages (from-to)	189-191
Number of pages	3
Journal	Schizophrenia Research
Volume	174
Issue number	1-3
DOIs	https://doi.org/10.1016/j.schres.2016.04.021
State	Published - Jul 1 2016
Externally published	Yes

Keywords

Cognition
Mismatch negativity
Schizophrenia
Target engagement
Transcranial direct current stimulation
tDCS

ASJC Scopus subject areas

Psychiatry and Mental health
Biological Psychiatry

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title = "Modulation of neurophysiological auditory processing measures by bilateral transcranial direct current stimulation in schizophrenia",

abstract = "This study used bilateral transcranial direct current stimulation (tDCS) to target neural generators of auditory Mismatch Negativity (MMN) and oddball P300 in schizophrenia patients. tDCS was applied to the pre-frontal cortex in a parallel between-group design. There was a significant main effect of stimulation resulting in modulation of MMN amplitude. This effect was mainly driven by a non-significant, but large, effect-size decrease in MMN amplitude with anodal stimulation. This is the first study to demonstrate that tDCS is able to engage and modulate an EEG-based auditory processing measure in schizophrenia.",

keywords = "Cognition, Mismatch negativity, Schizophrenia, Target engagement, Transcranial direct current stimulation, tDCS",

author = "Walter Dunn and Yuri Rassovsky and Wynn, {Jonathan K.} and Wu, {Allan D.} and Marco Iacoboni and Gerhard Hellemann and Green, {Michael F.}",

note = "Funding Information: This study was supported by the Veterans Administration (VA) Desert Pacific Veterans Integrated Service Network 22 (VISN 22) Mental Illness Research , Education and Clinical Center (MIRECC) infrastructure and by a NARSAD Independent Investigator Grant (PI: Yuri Rassovsky) from the Brain & Behavior Research Foundation ( 22017 ). Funding Information: This studywas supported by theVeterans Administration (VA)Desert Pacific Veterans Integrated Service Network 22 (VISN 22) Mental Illness Research, Education and Clinical Center (MIRECC) infrastructure and by a NARSAD Independent Investigator Grant (PI: Yuri Rassovsky) from the Brain & Behavior Research Foundation (22017). Publisher Copyright: {\textcopyright} 2016.",

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language = "English (US)",

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Modulation of neurophysiological auditory processing measures by bilateral transcranial direct current stimulation in schizophrenia. / Dunn, Walter; Rassovsky, Yuri; Wynn, Jonathan K.; Wu, Allan D.; Iacoboni, Marco; Hellemann, Gerhard; Green, Michael F.

In: Schizophrenia Research, Vol. 174, No. 1-3, 01.07.2016, p. 189-191.

Research output: Contribution to journal › Article › peer-review

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Modulation of neurophysiological auditory processing measures by bilateral transcranial direct current stimulation in schizophrenia

Abstract

Keywords

ASJC Scopus subject areas

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