Abstract
This study used bilateral transcranial direct current stimulation (tDCS) to target neural generators of auditory Mismatch Negativity (MMN) and oddball P300 in schizophrenia patients. tDCS was applied to the pre-frontal cortex in a parallel between-group design. There was a significant main effect of stimulation resulting in modulation of MMN amplitude. This effect was mainly driven by a non-significant, but large, effect-size decrease in MMN amplitude with anodal stimulation. This is the first study to demonstrate that tDCS is able to engage and modulate an EEG-based auditory processing measure in schizophrenia.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 189-191 |
| Number of pages | 3 |
| Journal | Schizophrenia Research |
| Volume | 174 |
| Issue number | 1-3 |
| DOIs | |
| State | Published - Jul 1 2016 |
Funding
This study was supported by the Veterans Administration (VA) Desert Pacific Veterans Integrated Service Network 22 (VISN 22) Mental Illness Research , Education and Clinical Center (MIRECC) infrastructure and by a NARSAD Independent Investigator Grant (PI: Yuri Rassovsky) from the Brain & Behavior Research Foundation ( 22017 ). This studywas supported by theVeterans Administration (VA)Desert Pacific Veterans Integrated Service Network 22 (VISN 22) Mental Illness Research, Education and Clinical Center (MIRECC) infrastructure and by a NARSAD Independent Investigator Grant (PI: Yuri Rassovsky) from the Brain & Behavior Research Foundation (22017).
Keywords
- Cognition
- Mismatch negativity
- Schizophrenia
- Target engagement
- Transcranial direct current stimulation
- tDCS
ASJC Scopus subject areas
- Psychiatry and Mental health
- Biological Psychiatry