Modulation of neurophysiological auditory processing measures by bilateral transcranial direct current stimulation in schizophrenia

Walter Dunn*, Yuri Rassovsky, Jonathan K. Wynn, Allan D. Wu, Marco Iacoboni, Gerhard Hellemann, Michael F. Green

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

14 Scopus citations

Abstract

This study used bilateral transcranial direct current stimulation (tDCS) to target neural generators of auditory Mismatch Negativity (MMN) and oddball P300 in schizophrenia patients. tDCS was applied to the pre-frontal cortex in a parallel between-group design. There was a significant main effect of stimulation resulting in modulation of MMN amplitude. This effect was mainly driven by a non-significant, but large, effect-size decrease in MMN amplitude with anodal stimulation. This is the first study to demonstrate that tDCS is able to engage and modulate an EEG-based auditory processing measure in schizophrenia.

Original languageEnglish (US)
Pages (from-to)189-191
Number of pages3
JournalSchizophrenia Research
Volume174
Issue number1-3
DOIs
StatePublished - Jul 1 2016
Externally publishedYes

Keywords

  • Cognition
  • Mismatch negativity
  • Schizophrenia
  • Target engagement
  • Transcranial direct current stimulation
  • tDCS

ASJC Scopus subject areas

  • Psychiatry and Mental health
  • Biological Psychiatry

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