Modulation of outflow resistance by the pores of the inner wall endothelium

M. Johnson*, A. Shapiro, C. R. Ethier, R. D. Kamm

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

113 Scopus citations


The juxtacanalicular connective tissue (JCT) is widely believed to generate the bulk of aqueous humor outflow resistance, while the pores of the inner wall endothelium are thought to generate at most 10% of this resistance in humans. However, the hydrodynamic interaction of these two components of the aqueous outflow system, which arises because of their spatial proximity, has only recently been considered. Modelling the JCT as a homogeneously distributed porous material upstream of a low porosity filter (the inner wall endothelium), the pores of the inner wall are found to cause a 'funneling effect,' in which the aqueous humor flows preferentially through those regions of the JCT nearest the inner wall pores. The bulk of the pressure drop occurs in the immediate proximity of the pores (within three pore radii). This greatly increases the apparent flow resistance of the JCT. For a set of parameters characterizing the normal eye, this enhancement is approximately 30-fold. The conclusion of this study is that changes in inner wall porosity may greatly affect aqueous outflow resistance, despite the low flow resistance of the inner wall pores themselves.

Original languageEnglish (US)
Pages (from-to)1670-1675
Number of pages6
JournalInvestigative Ophthalmology and Visual Science
Issue number5
StatePublished - 1992


  • aqueous outflow
  • aqueous outflow resistance
  • hydrodynamic
  • inner wall of Schlemm's canal
  • juxtacanalicular connective tissue
  • pores
  • porous media

ASJC Scopus subject areas

  • Ophthalmology
  • Sensory Systems
  • Cellular and Molecular Neuroscience


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