Modulation of TGF-β signaling by EGF-CFC proteins

Christian Wechselberger*, Caterina Bianco, Luigi Strizzi, Andreas D. Ebert, Nicholas Kenney, Youping Sun, David S. Salomon

*Corresponding author for this work

Research output: Contribution to journalShort survey

4 Scopus citations

Abstract

Members of the transforming growth factor-β (TGF-β) family of ligands exhibit potent growth-suppressive and/or apoptosis-inducing effects on different types of cells. They perform essential roles in the elimination of damaged or abnormal cells from healthy tissues. On the other hand, TGF-βs have also been shown to act as tumor-promoting cytokines in a number of malignancies that are capable of stimulating extracellular matrix production, cell migration, invasion, angiogenesis, and immune suppression. Dissecting the complex, multifaceted roles of different TGF-β-related peptides especially during the development of pathological conditions and in carcinogenesis is an area of continuous research and development. The characterization of EGF-CFC proteins as essential co-receptors that contribute to the modulation of the physiological activities of some of the TGF-β ligands will be beneficial for future medical research and the adaptation and possible readjustment of currently applied therapeutic regimes.

Original languageEnglish (US)
Pages (from-to)249-255
Number of pages7
JournalExperimental Cell Research
Volume310
Issue number2
DOIs
StatePublished - Nov 1 2005

Keywords

  • Apoptosis
  • Cancer
  • Cripto-1
  • EGF-CFC Proteins
  • Signal Transduction Cascades
  • TGF-β

ASJC Scopus subject areas

  • Cell Biology

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  • Cite this

    Wechselberger, C., Bianco, C., Strizzi, L., Ebert, A. D., Kenney, N., Sun, Y., & Salomon, D. S. (2005). Modulation of TGF-β signaling by EGF-CFC proteins. Experimental Cell Research, 310(2), 249-255. https://doi.org/10.1016/j.yexcr.2005.07.023