Modulation of TGF-β signaling by EGF-CFC proteins

Christian Wechselberger*, Caterina Bianco, Luigi Strizzi, Andreas D. Ebert, Nicholas Kenney, Youping Sun, David S. Salomon

*Corresponding author for this work

Research output: Contribution to journalShort survey

4 Citations (Scopus)

Abstract

Members of the transforming growth factor-β (TGF-β) family of ligands exhibit potent growth-suppressive and/or apoptosis-inducing effects on different types of cells. They perform essential roles in the elimination of damaged or abnormal cells from healthy tissues. On the other hand, TGF-βs have also been shown to act as tumor-promoting cytokines in a number of malignancies that are capable of stimulating extracellular matrix production, cell migration, invasion, angiogenesis, and immune suppression. Dissecting the complex, multifaceted roles of different TGF-β-related peptides especially during the development of pathological conditions and in carcinogenesis is an area of continuous research and development. The characterization of EGF-CFC proteins as essential co-receptors that contribute to the modulation of the physiological activities of some of the TGF-β ligands will be beneficial for future medical research and the adaptation and possible readjustment of currently applied therapeutic regimes.

Original languageEnglish (US)
Pages (from-to)249-255
Number of pages7
JournalExperimental Cell Research
Volume310
Issue number2
DOIs
StatePublished - Nov 1 2005

Fingerprint

Transforming Growth Factors
Epidermal Growth Factor
Proteins
Ligands
Cell Movement
Extracellular Matrix
Biomedical Research
Neoplasms
Carcinogenesis
Apoptosis
Cytokines
Peptides
Growth
Research
Therapeutics

Keywords

  • Apoptosis
  • Cancer
  • Cripto-1
  • EGF-CFC Proteins
  • Signal Transduction Cascades
  • TGF-β

ASJC Scopus subject areas

  • Cell Biology

Cite this

Wechselberger, C., Bianco, C., Strizzi, L., Ebert, A. D., Kenney, N., Sun, Y., & Salomon, D. S. (2005). Modulation of TGF-β signaling by EGF-CFC proteins. Experimental Cell Research, 310(2), 249-255. https://doi.org/10.1016/j.yexcr.2005.07.023
Wechselberger, Christian ; Bianco, Caterina ; Strizzi, Luigi ; Ebert, Andreas D. ; Kenney, Nicholas ; Sun, Youping ; Salomon, David S. / Modulation of TGF-β signaling by EGF-CFC proteins. In: Experimental Cell Research. 2005 ; Vol. 310, No. 2. pp. 249-255.
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Wechselberger, C, Bianco, C, Strizzi, L, Ebert, AD, Kenney, N, Sun, Y & Salomon, DS 2005, 'Modulation of TGF-β signaling by EGF-CFC proteins', Experimental Cell Research, vol. 310, no. 2, pp. 249-255. https://doi.org/10.1016/j.yexcr.2005.07.023

Modulation of TGF-β signaling by EGF-CFC proteins. / Wechselberger, Christian; Bianco, Caterina; Strizzi, Luigi; Ebert, Andreas D.; Kenney, Nicholas; Sun, Youping; Salomon, David S.

In: Experimental Cell Research, Vol. 310, No. 2, 01.11.2005, p. 249-255.

Research output: Contribution to journalShort survey

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AU - Strizzi, Luigi

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AU - Sun, Youping

AU - Salomon, David S.

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Wechselberger C, Bianco C, Strizzi L, Ebert AD, Kenney N, Sun Y et al. Modulation of TGF-β signaling by EGF-CFC proteins. Experimental Cell Research. 2005 Nov 1;310(2):249-255. https://doi.org/10.1016/j.yexcr.2005.07.023