Modulation of TGF-β signaling by EGF-CFC proteins

Christian Wechselberger; Caterina Bianco; Luigi Strizzi; Andreas D. Ebert; Nicholas Kenney; Youping Sun; David S. Salomon

doi:10.1016/j.yexcr.2005.07.023

Modulation of TGF-β signaling by EGF-CFC proteins

Christian Wechselberger^*, Caterina Bianco, Luigi Strizzi, Andreas D. Ebert, Nicholas Kenney, Youping Sun, David S. Salomon

^*Corresponding author for this work

Pathology

Research output: Contribution to journal › Short survey › peer-review

4 Scopus citations

Abstract

Members of the transforming growth factor-β (TGF-β) family of ligands exhibit potent growth-suppressive and/or apoptosis-inducing effects on different types of cells. They perform essential roles in the elimination of damaged or abnormal cells from healthy tissues. On the other hand, TGF-βs have also been shown to act as tumor-promoting cytokines in a number of malignancies that are capable of stimulating extracellular matrix production, cell migration, invasion, angiogenesis, and immune suppression. Dissecting the complex, multifaceted roles of different TGF-β-related peptides especially during the development of pathological conditions and in carcinogenesis is an area of continuous research and development. The characterization of EGF-CFC proteins as essential co-receptors that contribute to the modulation of the physiological activities of some of the TGF-β ligands will be beneficial for future medical research and the adaptation and possible readjustment of currently applied therapeutic regimes.

Original language	English (US)
Pages (from-to)	249-255
Number of pages	7
Journal	Experimental Cell Research
Volume	310
Issue number	2
DOIs	https://doi.org/10.1016/j.yexcr.2005.07.023
State	Published - Nov 1 2005

Keywords

Apoptosis
Cancer
Cripto-1
EGF-CFC Proteins
Signal Transduction Cascades
TGF-β

ASJC Scopus subject areas

Cell Biology

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title = "Modulation of TGF-β signaling by EGF-CFC proteins",

abstract = "Members of the transforming growth factor-β (TGF-β) family of ligands exhibit potent growth-suppressive and/or apoptosis-inducing effects on different types of cells. They perform essential roles in the elimination of damaged or abnormal cells from healthy tissues. On the other hand, TGF-βs have also been shown to act as tumor-promoting cytokines in a number of malignancies that are capable of stimulating extracellular matrix production, cell migration, invasion, angiogenesis, and immune suppression. Dissecting the complex, multifaceted roles of different TGF-β-related peptides especially during the development of pathological conditions and in carcinogenesis is an area of continuous research and development. The characterization of EGF-CFC proteins as essential co-receptors that contribute to the modulation of the physiological activities of some of the TGF-β ligands will be beneficial for future medical research and the adaptation and possible readjustment of currently applied therapeutic regimes.",

keywords = "Apoptosis, Cancer, Cripto-1, EGF-CFC Proteins, Signal Transduction Cascades, TGF-β",

author = "Christian Wechselberger and Caterina Bianco and Luigi Strizzi and Ebert, {Andreas D.} and Nicholas Kenney and Youping Sun and Salomon, {David S.}",

note = "Funding Information: This study was supported by grants from the Upper Austrian Government and from the Austrian Federal Ministry for Education, Science and Culture (bm:bwk) in the context of the Gen-AU project “Ultra-sensitive Proteomics and Genomics”.",

year = "2005",

month = nov,

day = "1",

doi = "10.1016/j.yexcr.2005.07.023",

language = "English (US)",

volume = "310",

pages = "249--255",

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T1 - Modulation of TGF-β signaling by EGF-CFC proteins

AU - Wechselberger, Christian

AU - Bianco, Caterina

AU - Strizzi, Luigi

AU - Ebert, Andreas D.

AU - Kenney, Nicholas

AU - Sun, Youping

AU - Salomon, David S.

N1 - Funding Information: This study was supported by grants from the Upper Austrian Government and from the Austrian Federal Ministry for Education, Science and Culture (bm:bwk) in the context of the Gen-AU project “Ultra-sensitive Proteomics and Genomics”.

PY - 2005/11/1

Y1 - 2005/11/1

N2 - Members of the transforming growth factor-β (TGF-β) family of ligands exhibit potent growth-suppressive and/or apoptosis-inducing effects on different types of cells. They perform essential roles in the elimination of damaged or abnormal cells from healthy tissues. On the other hand, TGF-βs have also been shown to act as tumor-promoting cytokines in a number of malignancies that are capable of stimulating extracellular matrix production, cell migration, invasion, angiogenesis, and immune suppression. Dissecting the complex, multifaceted roles of different TGF-β-related peptides especially during the development of pathological conditions and in carcinogenesis is an area of continuous research and development. The characterization of EGF-CFC proteins as essential co-receptors that contribute to the modulation of the physiological activities of some of the TGF-β ligands will be beneficial for future medical research and the adaptation and possible readjustment of currently applied therapeutic regimes.

AB - Members of the transforming growth factor-β (TGF-β) family of ligands exhibit potent growth-suppressive and/or apoptosis-inducing effects on different types of cells. They perform essential roles in the elimination of damaged or abnormal cells from healthy tissues. On the other hand, TGF-βs have also been shown to act as tumor-promoting cytokines in a number of malignancies that are capable of stimulating extracellular matrix production, cell migration, invasion, angiogenesis, and immune suppression. Dissecting the complex, multifaceted roles of different TGF-β-related peptides especially during the development of pathological conditions and in carcinogenesis is an area of continuous research and development. The characterization of EGF-CFC proteins as essential co-receptors that contribute to the modulation of the physiological activities of some of the TGF-β ligands will be beneficial for future medical research and the adaptation and possible readjustment of currently applied therapeutic regimes.

KW - Apoptosis

KW - Cancer

KW - Cripto-1

KW - EGF-CFC Proteins

KW - Signal Transduction Cascades

KW - TGF-β

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