Abstract
Members of the transforming growth factor-β (TGF-β) family of ligands exhibit potent growth-suppressive and/or apoptosis-inducing effects on different types of cells. They perform essential roles in the elimination of damaged or abnormal cells from healthy tissues. On the other hand, TGF-βs have also been shown to act as tumor-promoting cytokines in a number of malignancies that are capable of stimulating extracellular matrix production, cell migration, invasion, angiogenesis, and immune suppression. Dissecting the complex, multifaceted roles of different TGF-β-related peptides especially during the development of pathological conditions and in carcinogenesis is an area of continuous research and development. The characterization of EGF-CFC proteins as essential co-receptors that contribute to the modulation of the physiological activities of some of the TGF-β ligands will be beneficial for future medical research and the adaptation and possible readjustment of currently applied therapeutic regimes.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 249-255 |
| Number of pages | 7 |
| Journal | Experimental Cell Research |
| Volume | 310 |
| Issue number | 2 |
| DOIs | |
| State | Published - Nov 1 2005 |
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Keywords
- Apoptosis
- Cancer
- Cripto-1
- EGF-CFC Proteins
- Signal Transduction Cascades
- TGF-β
ASJC Scopus subject areas
- Cell Biology
Cite this
}
Modulation of TGF-β signaling by EGF-CFC proteins. / Wechselberger, Christian; Bianco, Caterina; Strizzi, Luigi; Ebert, Andreas D.; Kenney, Nicholas; Sun, Youping; Salomon, David S.
In: Experimental Cell Research, Vol. 310, No. 2, 01.11.2005, p. 249-255.Research output: Contribution to journal › Short survey
TY - JOUR
T1 - Modulation of TGF-β signaling by EGF-CFC proteins
AU - Wechselberger, Christian
AU - Bianco, Caterina
AU - Strizzi, Luigi
AU - Ebert, Andreas D.
AU - Kenney, Nicholas
AU - Sun, Youping
AU - Salomon, David S.
PY - 2005/11/1
Y1 - 2005/11/1
N2 - Members of the transforming growth factor-β (TGF-β) family of ligands exhibit potent growth-suppressive and/or apoptosis-inducing effects on different types of cells. They perform essential roles in the elimination of damaged or abnormal cells from healthy tissues. On the other hand, TGF-βs have also been shown to act as tumor-promoting cytokines in a number of malignancies that are capable of stimulating extracellular matrix production, cell migration, invasion, angiogenesis, and immune suppression. Dissecting the complex, multifaceted roles of different TGF-β-related peptides especially during the development of pathological conditions and in carcinogenesis is an area of continuous research and development. The characterization of EGF-CFC proteins as essential co-receptors that contribute to the modulation of the physiological activities of some of the TGF-β ligands will be beneficial for future medical research and the adaptation and possible readjustment of currently applied therapeutic regimes.
AB - Members of the transforming growth factor-β (TGF-β) family of ligands exhibit potent growth-suppressive and/or apoptosis-inducing effects on different types of cells. They perform essential roles in the elimination of damaged or abnormal cells from healthy tissues. On the other hand, TGF-βs have also been shown to act as tumor-promoting cytokines in a number of malignancies that are capable of stimulating extracellular matrix production, cell migration, invasion, angiogenesis, and immune suppression. Dissecting the complex, multifaceted roles of different TGF-β-related peptides especially during the development of pathological conditions and in carcinogenesis is an area of continuous research and development. The characterization of EGF-CFC proteins as essential co-receptors that contribute to the modulation of the physiological activities of some of the TGF-β ligands will be beneficial for future medical research and the adaptation and possible readjustment of currently applied therapeutic regimes.
KW - Apoptosis
KW - Cancer
KW - Cripto-1
KW - EGF-CFC Proteins
KW - Signal Transduction Cascades
KW - TGF-β
UR - http://www.scopus.com/inward/record.url?scp=26844505934&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=26844505934&partnerID=8YFLogxK
U2 - 10.1016/j.yexcr.2005.07.023
DO - 10.1016/j.yexcr.2005.07.023
M3 - Short survey
VL - 310
SP - 249
EP - 255
JO - Experimental Cell Research
JF - Experimental Cell Research
SN - 0014-4827
IS - 2
ER -