Modulation of tumor matrix by components of the plasminogen-plasmin system

Hau C. Kwaan*

*Corresponding author for this work

Research output: Chapter in Book/Report/Conference proceedingChapter


This chapter reviews the role of the components of the plasminogen-plasmin system as it pertains to tumor growth, invasion, and metastasis. The identification of an increased expression of urokinase type plasminogen activator (u-PA) in invasive and aggressive malignant tumors offers another important marker for prognostication. Using molecular gene transfer techniques, a tumor cell may be induced to alter its expression of these components of the plasminogen-plasmin system to perturb its growth pattern. The availability of plasmin, generated by u-PA, is an important step in cell migration in both physiologic and pathologic conditions. When homogenates of non-neoplastic human brain and brain tumor tissues have been examined by zymography and by enzyme-linked immunosorbent assay enzyme-linked immunosorbent assays (ELISA), u-PA and plasminogen activator inhibitor (PAI-1) were undetectable in non-neoplastic brain. U-PA and PAI-1 ELISA may offer a potential biomarker and biologic response modifier for the growth of human brain tumors.

Original languageEnglish (US)
Title of host publicationTumor Matrix Biology
PublisherCRC Press
Number of pages20
ISBN (Electronic)9781351355803
ISBN (Print)9781138550476
StatePublished - Jan 1 2017

ASJC Scopus subject areas

  • Medicine(all)


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