Molecular analysis of Philadelphia positive essential thrombocythemia

P. Martiat, N. Ifrah, F. Rassool, G. Morgan, F. Giles, J. Gow, J. M. Goldman

Research output: Contribution to journalArticlepeer-review

46 Scopus citations

Abstract

Seven patients with Philadelphia (Ph) chromosome positive essential thrombocythemia (ET) were investigated for the presence of a rearrangement within the major breakpoint cluster region (M-bcr) using the Southern blot technique and, in six cases, for the presence of the hybrid bcr-abl mRNA using the polymerase chain reaction (PCR). The molecular studies showed rearrangement of M-bcr in all cases; there was evidence of the b2a2 mRNA junction in one case and of b3a2 junction in five cases. These findings are identical to what might have been expected in Ph-positive chronic myeloid leukemia. These features may explain the poor prognosis of Ph-positive ET in comparison with cytogenetically normal cases. Conversely, the differences in clinical presentation may be due to other genetic changes.

Original languageEnglish (US)
Pages (from-to)563-565
Number of pages3
JournalLeukemia
Volume3
Issue number8
StatePublished - 1989

ASJC Scopus subject areas

  • Hematology
  • Oncology
  • Cancer Research

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