Molecular Assessment of Thyroid Nodules

Mayumi Endo; Dina M. Elaraj; Neda A. Moatamed; Richard T. Kloos

doi:10.1007/978-3-030-73951-5_2

Molecular Assessment of Thyroid Nodules

Mayumi Endo^*, Dina M. Elaraj, Neda A. Moatamed, Richard T. Kloos

^*Corresponding author for this work

Surgery, Surgical Oncology Division

Research output: Chapter in Book/Report/Conference proceeding › Chapter

1 Scopus citations

Abstract

Our understanding of the genomics of benign and malignant thyroid nodules has advanced rapidly, and so have the applications that utilize this information for clinical decision-making. Not long ago, it was “cutting-edge” medicine to test for a single genomic variant. Now, everyday practitioners have access to gene panels and genomic classifiers that utilize hundreds and thousands of genes. Here, we discuss current cytological nomenclature of thyroid aspirates, review cellular genomics, discuss current genomic tests for cytologically indeterminate nodules, consider surgical decision-making, explore the potential role of genomics among suspicious and malignant cytology categories, and consider future directions.

Original language	English (US)
Title of host publication	Innovations in Modern Endocrine Surgery
Publisher	Springer International Publishing
Pages	21-54
Number of pages	34
ISBN (Electronic)	9783030739515
ISBN (Print)	9783030739508
DOIs	https://doi.org/10.1007/978-3-030-73951-5_2
State	Published - Jan 1 2021

Keywords

Genomics
Molecular diagnostics
Molecular testing
Thyroid cancer
Thyroid nodule

ASJC Scopus subject areas

Medicine(all)

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1007/978-3-030-73951-5_2

Cite this

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title = "Molecular Assessment of Thyroid Nodules",

abstract = "Our understanding of the genomics of benign and malignant thyroid nodules has advanced rapidly, and so have the applications that utilize this information for clinical decision-making. Not long ago, it was “cutting-edge” medicine to test for a single genomic variant. Now, everyday practitioners have access to gene panels and genomic classifiers that utilize hundreds and thousands of genes. Here, we discuss current cytological nomenclature of thyroid aspirates, review cellular genomics, discuss current genomic tests for cytologically indeterminate nodules, consider surgical decision-making, explore the potential role of genomics among suspicious and malignant cytology categories, and consider future directions.",

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author = "Mayumi Endo and Elaraj, {Dina M.} and Moatamed, {Neda A.} and Kloos, {Richard T.}",

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AU - Endo, Mayumi

AU - Elaraj, Dina M.

AU - Moatamed, Neda A.

AU - Kloos, Richard T.

N1 - Publisher Copyright: © Springer Nature Switzerland AG 2021.

PY - 2021/1/1

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AB - Our understanding of the genomics of benign and malignant thyroid nodules has advanced rapidly, and so have the applications that utilize this information for clinical decision-making. Not long ago, it was “cutting-edge” medicine to test for a single genomic variant. Now, everyday practitioners have access to gene panels and genomic classifiers that utilize hundreds and thousands of genes. Here, we discuss current cytological nomenclature of thyroid aspirates, review cellular genomics, discuss current genomic tests for cytologically indeterminate nodules, consider surgical decision-making, explore the potential role of genomics among suspicious and malignant cytology categories, and consider future directions.

KW - Genomics

KW - Molecular diagnostics

KW - Molecular testing

KW - Thyroid cancer

KW - Thyroid nodule

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ER -

Molecular Assessment of Thyroid Nodules

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

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