Molecular basis of inherited epilepsy

Alfred L. George*

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

24 Scopus citations


Epilepsy is a common, paroxysmal, and heterogeneous neurological disorder. Many factors, including complex genetic influences, contribute to the pathogenesis of epilepsy. However, several epilepsy syndromes are caused by mutations in single genes (Table). Most epilepsy-associated genes that have been identified within the past 5 years encode ion channels. This review illustrates the progress in defining the molecular basis of inherited epilepsies and highlights conditions caused by dysfunctional ion channels.

Original languageEnglish (US)
Pages (from-to)473-478
Number of pages6
JournalArchives of Neurology
Issue number4
StatePublished - Apr 2004

ASJC Scopus subject areas

  • Clinical Neurology
  • Arts and Humanities (miscellaneous)


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