Abstract
Epilepsy is a common, paroxysmal, and heterogeneous neurological disorder. Many factors, including complex genetic influences, contribute to the pathogenesis of epilepsy. However, several epilepsy syndromes are caused by mutations in single genes (Table). Most epilepsy-associated genes that have been identified within the past 5 years encode ion channels. This review illustrates the progress in defining the molecular basis of inherited epilepsies and highlights conditions caused by dysfunctional ion channels.
Original language | English (US) |
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Pages (from-to) | 473-478 |
Number of pages | 6 |
Journal | Archives of Neurology |
Volume | 61 |
Issue number | 4 |
DOIs | |
State | Published - Apr 2004 |
ASJC Scopus subject areas
- Clinical Neurology
- Arts and Humanities (miscellaneous)