TY - JOUR
T1 - Molecular basis of inherited epilepsy
AU - George, Alfred L.
N1 - Copyright:
Copyright 2008 Elsevier B.V., All rights reserved.
PY - 2004/4
Y1 - 2004/4
N2 - Epilepsy is a common, paroxysmal, and heterogeneous neurological disorder. Many factors, including complex genetic influences, contribute to the pathogenesis of epilepsy. However, several epilepsy syndromes are caused by mutations in single genes (Table). Most epilepsy-associated genes that have been identified within the past 5 years encode ion channels. This review illustrates the progress in defining the molecular basis of inherited epilepsies and highlights conditions caused by dysfunctional ion channels.
AB - Epilepsy is a common, paroxysmal, and heterogeneous neurological disorder. Many factors, including complex genetic influences, contribute to the pathogenesis of epilepsy. However, several epilepsy syndromes are caused by mutations in single genes (Table). Most epilepsy-associated genes that have been identified within the past 5 years encode ion channels. This review illustrates the progress in defining the molecular basis of inherited epilepsies and highlights conditions caused by dysfunctional ion channels.
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U2 - 10.1001/archneur.61.4.473
DO - 10.1001/archneur.61.4.473
M3 - Review article
C2 - 15096393
AN - SCOPUS:2342629242
VL - 61
SP - 473
EP - 478
JO - Archives of Neurology
JF - Archives of Neurology
SN - 0003-9942
IS - 4
ER -