Molecular basis of neonatal cholestasis

Karan Mc Bride Emerick, Peter F. Whitington

Research output: Contribution to journalReview articlepeer-review

29 Scopus citations


At present, specific evidence regarding the molecular mechanisms of neonatal cholestasis is limited. The recent explosion in the understanding of the molecular physiology of bile formation has been fueled by the discovery of several genes that are involved in familial cholestasis. The ever-growing understanding of the functional immaturity of the neonatal liver is sure to be enhanced by the study of the ontogeny of important hepatobiliary transporters as they are discovered. The understanding of the functional differences between the immature and mature liver is key to the understanding of neonatal cholestasis.

Original languageEnglish (US)
Pages (from-to)221-235
Number of pages15
JournalPediatric Clinics of North America
Issue number1
StatePublished - 2002

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health


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