Molecular basis of transplant rejection and acceptance

Alan M. Krensky*

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

2 Scopus citations


The field of kidney transplantation is advancing so rapidly that it is difficult to keep up with the various therapeutic protocols, let alone our current understanding of transplantation immunobiology. This basic science review summarizes our current understanding of aspects of the cellular and molecular basis of renal transplant rejection and then details studies from the author's laboratory designed to specifically interrupt transplant rejection. The interaction of HLA with T cell receptors and the cascade of events following T cell activation are highlighted.

Original languageEnglish (US)
Pages (from-to)422-427
Number of pages6
JournalPediatric Nephrology
Issue number4
StatePublished - Jul 1991


  • HLA
  • T cell activation
  • T cell receptor
  • T lymphocytes
  • Transplantation
  • transplant rejection

ASJC Scopus subject areas

  • Nephrology
  • Pediatrics, Perinatology, and Child Health


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