Molecular biology of breast cancer metastasis. Molecular expression of vascular markers by aggressive breast cancer cells

M. J.C. Hendrix*, E. A. Seftor, D. A. Kirschmann, R. E.B. Seftor

*Corresponding author for this work

Research output: Contribution to journalReview article

83 Scopus citations

Abstract

During embryogenesis, the formation of primary vascular networks occurs via the processes of vasculogenesis and angiogenesis. In uveal melanoma, vasculogenic mimicry describes the 'embryonic-like' ability of aggressive, but not nonaggressive, tumor cells to form networks surrounding spheroids of tumor cells in three-dimensional culture; these recapitulate the patterned networks seen in patients' aggressive tumors and correlates with poor prognosis. The molecular profile of these aggressive tumor cells suggests that they have a deregulated genotype, capable of expressing vascular phenotypes. Similarly, the embryonic-like phenotype expressed by the aggressive human breast cancer cells is associated with their ability to express a variety of vascular markers. These studies may offer new insights for consideration in breast cancer diagnosis and therapeutic intervention strategies.

Original languageEnglish (US)
Pages (from-to)417-422
Number of pages6
JournalBreast Cancer Research
Volume2
Issue number6
DOIs
StatePublished - 2000

Keywords

  • Breast cancer
  • Interconverted phenotype
  • TIE2
  • Thrombin receptor

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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