Molecular Biology of Pituitary Adenomas

Claire M. Faltermeier, Stephen T. Magill, Lewis S. Blevins, Manish K. Aghi*

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

10 Scopus citations

Abstract

Pituitary adenomas are benign tumors, but still cause significant morbidity and in some cases increases in mortality. Surgical resection is not without risks, and approximately 40% of adenomas are incompletely resected. Medical therapies such as dopamine agonists, somatostatin analogues, and growth hormone antagonists are associated with numerous side effects. Understanding the molecular biology of pituitary adenomas may yield new therapeutic approaches. Additional studies are needed to help determine which genes or pathways are “drivers” of tumorigenesis and should be therapeutic targets. Further studies may also enable pituitary adenoma stratification to tailor treatment approaches.

Original languageEnglish (US)
Pages (from-to)391-400
Number of pages10
JournalNeurosurgery clinics of North America
Volume30
Issue number4
DOIs
StatePublished - Oct 2019
Externally publishedYes

Keywords

  • Corticotroph adenomas
  • Gonadotroph adenomas
  • Lactotroph adenomas
  • Molecular biology
  • Null cell adenomas
  • Pituitary adenomas
  • Somatotroph adenomas
  • Thyrotroph adenomas

ASJC Scopus subject areas

  • Surgery
  • Clinical Neurology

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