Molecular characterization of acute myeloid leukemia and its impact on treatment

Olga Frankfurt*, Jonathan D. Licht, Martin S. Tallman

*Corresponding author for this work

Research output: Contribution to journalReview article

24 Scopus citations

Abstract

PURPOSE OF REVIEW: Molecular aberrations are playing an ever increasing role in guiding classification, prognosis, and therapeutic strategies in patients with acute myeloid leukemia. This review outlines recent strides in our understanding of the molecular characteristics of acute myeloid leukemia. RECENT FINDINGS: We highlight the novel concept of preferential co-expression of certain mutations, summarize recent data on the clinically relevant prognostic role of known and novel molecular aberrations, and emphasize the emerging role of gene expression profiling and minimal residual disease monitoring. SUMMARY: We review the molecular heterogeneity within already established categories of acute myeloid leukemia and discuss how these data may translate into prognostic, molecular-based therapy stratification to improve patient outcome.

Original languageEnglish (US)
Pages (from-to)635-649
Number of pages15
JournalCurrent opinion in oncology
Volume19
Issue number6
DOIs
StatePublished - Nov 1 2007

Keywords

  • Acute myeloid leukemia
  • Acute promyelocytic leukemia
  • Core-binding factor leukemia
  • Cytogenetically normal acute myeloid leukemia
  • Cytogenetics
  • Molecular analysis

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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