Molecular cloning and tissue expression of a novel orphan G protein-coupled receptor from rat lung

James A. Bonini*, Spencer M. Anderson, Donald F. Steiner

*Corresponding author for this work

Research output: Contribution to journalArticle

37 Scopus citations

Abstract

G protein coupled receptors transduce the signal of a wide variety of hormones, neurotransmitters, cytokines, and other molecules across the cell membrane to elicit the corresponding response inside the target cells. We describe in this paper the molecular cloning and tissue distribution of a novel rat G protein-coupled receptor, GPR41, with highest homology to the human orphan G protein-coupled receptor DRY12. A lower degree of homology was seen with the receptors for bradykinin, angiotensin, and IL8. The expression of GPR41 appears to be the highest in brain and lung tissues, with lesser expression in heart, skeletal muscle, and kidney, as assayed by northern blotting. No GPR41 message was seen in spleen, liver, or testes. GPR41 failed to bind any of the ligands tested.

Original languageEnglish (US)
Pages (from-to)190-193
Number of pages4
JournalBiochemical and Biophysical Research Communications
Volume234
Issue number1
DOIs
StatePublished - May 8 1997

ASJC Scopus subject areas

  • Biophysics
  • Biochemistry
  • Molecular Biology
  • Cell Biology

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