Molecular control of monocyte development

Rachael L. Terry; Stephen D. Miller

doi:10.1016/j.cellimm.2014.02.008

Molecular control of monocyte development

Rachael L. Terry, Stephen D. Miller^*

^*Corresponding author for this work

Microbiology-Immunology

Research output: Contribution to journal › Article › peer-review

46 Scopus citations

Abstract

Monocyte development is a tightly regulated and multi-staged process, occurring through several defined progenitor cell intermediates. The key transcription factors, including PU.1, IRF8 and KLF4, growth factors, such as M-CSF and IL-34 and cytokines that drive monocyte development from hematopoietic progenitor cells are well defined. However, the molecular controls that direct differentiation into the Ly6C^hi inflammatory and Ly6C^lo monocyte subsets are yet to be completely elucidated. This review will provide a summary of the transcriptional regulation of monocyte development. We will also discuss how these molecular controls are also critical for microglial development despite their distinct haematopoetic origins. Furthermore, we will examine recent breakthroughs in defining mechanisms that promote differentiation of specific monocyte subpopulations.

Original language	English (US)
Pages (from-to)	16-21
Number of pages	6
Journal	Cellular Immunology
Volume	291
Issue number	1-2
DOIs	https://doi.org/10.1016/j.cellimm.2014.02.008
State	Published - Sep 1 2014

Keywords

IRF8
KLF4
Ly6C monocytes
Microglia
Monocyte development
NR4A1
PU.1
Transcription factors

ASJC Scopus subject areas

Immunology

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10.1016/j.cellimm.2014.02.008

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title = "Molecular control of monocyte development",

abstract = "Monocyte development is a tightly regulated and multi-staged process, occurring through several defined progenitor cell intermediates. The key transcription factors, including PU.1, IRF8 and KLF4, growth factors, such as M-CSF and IL-34 and cytokines that drive monocyte development from hematopoietic progenitor cells are well defined. However, the molecular controls that direct differentiation into the Ly6Chi inflammatory and Ly6Clo monocyte subsets are yet to be completely elucidated. This review will provide a summary of the transcriptional regulation of monocyte development. We will also discuss how these molecular controls are also critical for microglial development despite their distinct haematopoetic origins. Furthermore, we will examine recent breakthroughs in defining mechanisms that promote differentiation of specific monocyte subpopulations.",

keywords = "IRF8, KLF4, Ly6C monocytes, Microglia, Monocyte development, NR4A1, PU.1, Transcription factors",

author = "Terry, {Rachael L.} and Miller, {Stephen D.}",

note = "Funding Information: Supported in part by NIH Grants EB 013198 and NS 026543 . Publisher Copyright: {\textcopyright} 2014 Elsevier Inc..",

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doi = "10.1016/j.cellimm.2014.02.008",

language = "English (US)",

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journal = "Cellular Immunology",

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AU - Miller, Stephen D.

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AB - Monocyte development is a tightly regulated and multi-staged process, occurring through several defined progenitor cell intermediates. The key transcription factors, including PU.1, IRF8 and KLF4, growth factors, such as M-CSF and IL-34 and cytokines that drive monocyte development from hematopoietic progenitor cells are well defined. However, the molecular controls that direct differentiation into the Ly6Chi inflammatory and Ly6Clo monocyte subsets are yet to be completely elucidated. This review will provide a summary of the transcriptional regulation of monocyte development. We will also discuss how these molecular controls are also critical for microglial development despite their distinct haematopoetic origins. Furthermore, we will examine recent breakthroughs in defining mechanisms that promote differentiation of specific monocyte subpopulations.

KW - IRF8

KW - KLF4

KW - Ly6C monocytes

KW - Microglia

KW - Monocyte development

KW - NR4A1

KW - PU.1

KW - Transcription factors

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Molecular control of monocyte development

Abstract

Keywords

ASJC Scopus subject areas

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