Molecular diagnostics of gliomas: The clinical perspective

Ghazaleh Tabatabai*, Roger Stupp, Martin J. Van Den Bent, Monika E. Hegi, Jörg C. Tonn, Wolfgang Wick, Michael Weller

*Corresponding author for this work

Research output: Contribution to journalReview article

91 Scopus citations

Abstract

Significant progress has been made in the molecular diagnostic subtyping of brain tumors, in particular gliomas. In contrast to the classical molecular markers in this field, p53 and epidermal growth factor receptor (EGFR) status, the clinical significance of which has remained controversial, at least three important molecular markers with clinical implications have now been identified: 1p/19q codeletion, O 6-methylguanine methyltransferase (MGMT) promoter methylation and isocitrate dehydrogenase-1 (IDH1) mutations. All three are favorable prognostic markers. 1p/19q codeletion and IDH1 mutations are also useful to support and extend the histological classification of gliomas since they are strongly linked to oligodendroglial morphology and grade II/III gliomas, as opposed to glioblastoma, respectively. MGMT promoter methylation is the only potentially predictive marker, at least for alkylating agent chemotherapy in glioblastoma. Beyond these classical markers, the increasing repertoire of anti-angiogenic agents that are currently explored within registration trials for gliomas urgently calls for efforts to identify molecular markers that predict the benefit derived from these novel treatments, too.

Original languageEnglish (US)
Pages (from-to)585-592
Number of pages8
JournalActa Neuropathologica
Volume120
Issue number5
DOIs
StatePublished - Nov 1 2010

Keywords

  • Clinical neurooncology
  • Clinical trials
  • Malignant gliomas
  • Molecular diagnostic
  • Prognostic factor

ASJC Scopus subject areas

  • Pathology and Forensic Medicine
  • Clinical Neurology
  • Cellular and Molecular Neuroscience

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  • Cite this

    Tabatabai, G., Stupp, R., Van Den Bent, M. J., Hegi, M. E., Tonn, J. C., Wick, W., & Weller, M. (2010). Molecular diagnostics of gliomas: The clinical perspective. Acta Neuropathologica, 120(5), 585-592. https://doi.org/10.1007/s00401-010-0750-6