Molecular evolution of the urate oxidase-encoding gene in hominoid primates: nonsense mutations

Anjana V. Yeldandi*, Vijay Yeldandi, Sujata Kumar, C. V. Narasimha Murthy, Xuedong Wang, Alvares Keith, M. Sambasiva Rao, Janardan K. Reddy

*Corresponding author for this work

Research output: Contribution to journalArticle

90 Scopus citations

Abstract

Nucleotide sequences of portions of second and fifth exons of urate oxidase encoding gene (UOX) of chimpanzee, gorilla, orangutan, rhesus monkey and squirrel monkey obtained following amplification by polymerase chain reaction have been compared with corresponding sequences of human, baboon and rat (UOX). Two or more nonsense mutations are found in the coding regions of this UOX gene thus far analyzed in human, chimpanzee, gorilla and orangutan, but not in the baboon, rhesus monkey and squirrel monkey. Of these nonsense mutations, the stop codon at amino acid position 33 is constant in the human and the three great suggesting that this may be the original mutation responsible for the inactivation of the UOX gene during hominoid evolution.

Original languageEnglish (US)
Pages (from-to)281-284
Number of pages4
JournalGene
Volume109
Issue number2
DOIs
StatePublished - Dec 30 1991

Keywords

  • Recombinant DNA
  • chimpanzee
  • exon
  • gorilla
  • orangutan
  • peroxisome
  • polymerase chain reaction
  • rhesus monkey
  • squirrel monkey

ASJC Scopus subject areas

  • Genetics

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