Molecular genetic aspects of glial tumour evolution

C. D. James, T. Mikkelsen, W. K. Cavenee, V. P. Collins

Research output: Contribution to journalReview articlepeer-review

13 Scopus citations


Cancer can be viewed as a dynamic process driven by the cellular accumulation of genetic alterations that provide selective growth advantage. Such alterations can be classified as one of two fundamental types : acquired (cancer-affective, dominant) or eliminated (cancer suppressive, recessive). This review considers genetic alterations that occur during the development of the most common type of central nervous system tumour, glioma.

Original languageEnglish (US)
Pages (from-to)631-644
Number of pages14
JournalCancer Surveys
Issue number4
StatePublished - Dec 1 1990


  • RFLP analysis
  • clonal evolution
  • dominant
  • loss of genetic information
  • malignancy grade
  • primary or secondary genetic alteration
  • recessive
  • tumour evolution
  • tumour progression
  • tumour suppression

ASJC Scopus subject areas

  • Oncology
  • Cancer Research


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