Abstract
Juvenile dermatomyositis (JDMS) is an inflammatory disease associated with HLA-DR3. We therefore undertook molecular genetic studies of HLA region genes to determine whether HLA-DR3 itself confers susceptibility to JDMS or whether susceptibility is conferred by alleles in linkage disequilibrium with HLA-DR3. Our results indicate that JDMS is associated with the HLA-DQA1 allele DQA1*0501 on non-DR3 haplotypes in Caucasian JDMS. Furthermore, the reported of association between the C4A gene deletion and JDMS is likely due to linkage disequilibrium with HLA-DR3. Human Immunology 32, 235-240 (1991).
| Original language | English (US) |
|---|---|
| Pages (from-to) | 235-240 |
| Number of pages | 6 |
| Journal | Human Immunology |
| Volume | 32 |
| Issue number | 4 |
| DOIs | |
| State | Published - Dec 1991 |
Funding
ACKNOWLEDGMENTS This work was supported in part by grants from the National Arthritis Foundation and the Marlerm Apfelbaum Foundation m LP. and NIH Grant HD21244 to C. O.
ASJC Scopus subject areas
- Immunology and Allergy
- Immunology