Abstract
Human Leukocyte Antigens (HLA) matching at the serological level used to serve as the measure of histocompatibility between organ donors and recipients. With advancements in HLA typing methods more precise HLA mismatch assessment tools were developed to measure dissimilarities at the molecular level, collectively referred to as Molecular Mismatch load analysis tools. Currently, several software are aimed at deciphering the dissimilarities using somewhat different immunologic rationales. Our goal, in this review is to provide a basic overview of the different computational approaches, provide clinical cases to contextualize concerns regarding the lack of assessment of immunogenicity, and present our personal view regarding the gaps and the needs of our field.
Original language | English (US) |
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Pages (from-to) | 233-240 |
Number of pages | 8 |
Journal | Human Immunology |
Volume | 83 |
Issue number | 3 |
DOIs | |
State | Published - Mar 2022 |
Funding
Dr. Anat R. Tambur is a Paul I. Terasaki scholar. This work was supported in part by Paul I. Terasaki foundation.
Keywords
- Epitope
- HLA
- Immunogenicity
- Molecular Mismatch
ASJC Scopus subject areas
- Immunology and Allergy
- Immunology