Molecular histocompatibility beyond Tears: The next generation version

Nida Saleem; Rajdeep Das; Anat R. Tambur

doi:10.1016/j.humimm.2021.12.005

Molecular histocompatibility beyond Tears: The next generation version

Nida Saleem, Rajdeep Das, Anat R. Tambur^*

^*Corresponding author for this work

Surgery, Transplant Surgery Division

Research output: Contribution to journal › Article › peer-review

2 Scopus citations

Abstract

Human Leukocyte Antigens (HLA) matching at the serological level used to serve as the measure of histocompatibility between organ donors and recipients. With advancements in HLA typing methods more precise HLA mismatch assessment tools were developed to measure dissimilarities at the molecular level, collectively referred to as Molecular Mismatch load analysis tools. Currently, several software are aimed at deciphering the dissimilarities using somewhat different immunologic rationales. Our goal, in this review is to provide a basic overview of the different computational approaches, provide clinical cases to contextualize concerns regarding the lack of assessment of immunogenicity, and present our personal view regarding the gaps and the needs of our field.

Original language	English (US)
Pages (from-to)	233-240
Number of pages	8
Journal	Human Immunology
Volume	83
Issue number	3
DOIs	https://doi.org/10.1016/j.humimm.2021.12.005
State	Published - Mar 2022

Keywords

Epitope
HLA
Immunogenicity
Molecular Mismatch

ASJC Scopus subject areas

Immunology and Allergy
Immunology

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10.1016/j.humimm.2021.12.005

Cite this

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title = "Molecular histocompatibility beyond Tears: The next generation version",

abstract = "Human Leukocyte Antigens (HLA) matching at the serological level used to serve as the measure of histocompatibility between organ donors and recipients. With advancements in HLA typing methods more precise HLA mismatch assessment tools were developed to measure dissimilarities at the molecular level, collectively referred to as Molecular Mismatch load analysis tools. Currently, several software are aimed at deciphering the dissimilarities using somewhat different immunologic rationales. Our goal, in this review is to provide a basic overview of the different computational approaches, provide clinical cases to contextualize concerns regarding the lack of assessment of immunogenicity, and present our personal view regarding the gaps and the needs of our field.",

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AB - Human Leukocyte Antigens (HLA) matching at the serological level used to serve as the measure of histocompatibility between organ donors and recipients. With advancements in HLA typing methods more precise HLA mismatch assessment tools were developed to measure dissimilarities at the molecular level, collectively referred to as Molecular Mismatch load analysis tools. Currently, several software are aimed at deciphering the dissimilarities using somewhat different immunologic rationales. Our goal, in this review is to provide a basic overview of the different computational approaches, provide clinical cases to contextualize concerns regarding the lack of assessment of immunogenicity, and present our personal view regarding the gaps and the needs of our field.

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Molecular histocompatibility beyond Tears: The next generation version

Abstract

Keywords

ASJC Scopus subject areas

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