Molecular histocompatibility beyond Tears: The next generation version

Nida Saleem, Rajdeep Das, Anat R. Tambur*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

2 Scopus citations

Abstract

Human Leukocyte Antigens (HLA) matching at the serological level used to serve as the measure of histocompatibility between organ donors and recipients. With advancements in HLA typing methods more precise HLA mismatch assessment tools were developed to measure dissimilarities at the molecular level, collectively referred to as Molecular Mismatch load analysis tools. Currently, several software are aimed at deciphering the dissimilarities using somewhat different immunologic rationales. Our goal, in this review is to provide a basic overview of the different computational approaches, provide clinical cases to contextualize concerns regarding the lack of assessment of immunogenicity, and present our personal view regarding the gaps and the needs of our field.

Original languageEnglish (US)
Pages (from-to)233-240
Number of pages8
JournalHuman Immunology
Volume83
Issue number3
DOIs
StatePublished - Mar 2022

Keywords

  • Epitope
  • HLA
  • Immunogenicity
  • Molecular Mismatch

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

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