Molecular imaging of in vivo gene expression

Allison S. Harney, Thomas J. Meade

Research output: Contribution to journalReview articlepeer-review

16 Scopus citations

Abstract

Molecular imaging provides spatial and temporal information on cellular changes that occur during development and in disease. MRI and optical imaging of reporter genes allows for the visualization of promoter activity, protein-protein interactions, protein stability and the tracking of individual proteins and cells. Reporter genes can be genetically encoded in transgenic animals or detected through the administration of an exogenous contrast agent. Advances in molecular imaging of reporter genes have led to the development of imaging probes that detect changes in endogenous cellular changes. The ability to use contrast agents coupled with functional information on cellular events will allow for sensitive assessment of individual patient therapies, leading to an accurately tailored treatment regimen.

Original languageEnglish (US)
Pages (from-to)503-519
Number of pages17
JournalFuture Medicinal Chemistry
Volume2
Issue number3
DOIs
StatePublished - Mar 2010

ASJC Scopus subject areas

  • Molecular Medicine
  • Pharmacology
  • Drug Discovery

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