TY - JOUR
T1 - Molecular implementation and physiological roles for histone H3 lysine 4 (H3K4) methylation
AU - Shilatifard, Ali
N1 - Funding Information:
I am grateful to Dr Edwin Smith for critical reading of this review and Laura Shilatifard for editorial assistance. The research in Shilatifard's Laboratory is supported by grants from the National Institutes of Health (2R01CA089455 and 1R01GM069905).
PY - 2008/6
Y1 - 2008/6
N2 - Chromosomal surfaces are ornamented with a variety of post-translational modifications of histones, which are required for the regulation of many of the DNA-templated processes. Such histone modifications include acetylation, sumoylation, phosphorylation, ubiquitination, and methylation. Histone modifications can either function by disrupting chromosomal contacts or by regulating non-histone protein interactions with chromatin. In this review, recent findings will be discussed regarding the regulation of the implementation and physiological significance for one such histone modification, histone H3 lysine 4 (H3K4) methylation by the yeast COMPASS and mammalian COMPASS-like complexes.
AB - Chromosomal surfaces are ornamented with a variety of post-translational modifications of histones, which are required for the regulation of many of the DNA-templated processes. Such histone modifications include acetylation, sumoylation, phosphorylation, ubiquitination, and methylation. Histone modifications can either function by disrupting chromosomal contacts or by regulating non-histone protein interactions with chromatin. In this review, recent findings will be discussed regarding the regulation of the implementation and physiological significance for one such histone modification, histone H3 lysine 4 (H3K4) methylation by the yeast COMPASS and mammalian COMPASS-like complexes.
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U2 - 10.1016/j.ceb.2008.03.019
DO - 10.1016/j.ceb.2008.03.019
M3 - Review article
C2 - 18508253
AN - SCOPUS:44649139771
SN - 0955-0674
VL - 20
SP - 341
EP - 348
JO - Current Opinion in Cell Biology
JF - Current Opinion in Cell Biology
IS - 3
ER -