Molecular implementation and physiological roles for histone H3 lysine 4 (H3K4) methylation

Ali Shilatifard*

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

383 Scopus citations


Chromosomal surfaces are ornamented with a variety of post-translational modifications of histones, which are required for the regulation of many of the DNA-templated processes. Such histone modifications include acetylation, sumoylation, phosphorylation, ubiquitination, and methylation. Histone modifications can either function by disrupting chromosomal contacts or by regulating non-histone protein interactions with chromatin. In this review, recent findings will be discussed regarding the regulation of the implementation and physiological significance for one such histone modification, histone H3 lysine 4 (H3K4) methylation by the yeast COMPASS and mammalian COMPASS-like complexes.

Original languageEnglish (US)
Pages (from-to)341-348
Number of pages8
JournalCurrent Opinion in Cell Biology
Issue number3
StatePublished - Jun 2008

ASJC Scopus subject areas

  • Cell Biology


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