Molecular implementation and physiological roles for histone H3 lysine 4 (H3K4) methylation

Ali Shilatifard

doi:10.1016/j.ceb.2008.03.019

Molecular implementation and physiological roles for histone H3 lysine 4 (H3K4) methylation

Ali Shilatifard^*

^*Corresponding author for this work

Biochemistry and Molecular Genetics

Research output: Contribution to journal › Review article › peer-review

401 Scopus citations

Abstract

Chromosomal surfaces are ornamented with a variety of post-translational modifications of histones, which are required for the regulation of many of the DNA-templated processes. Such histone modifications include acetylation, sumoylation, phosphorylation, ubiquitination, and methylation. Histone modifications can either function by disrupting chromosomal contacts or by regulating non-histone protein interactions with chromatin. In this review, recent findings will be discussed regarding the regulation of the implementation and physiological significance for one such histone modification, histone H3 lysine 4 (H3K4) methylation by the yeast COMPASS and mammalian COMPASS-like complexes.

Original language	English (US)
Pages (from-to)	341-348
Number of pages	8
Journal	Current Opinion in Cell Biology
Volume	20
Issue number	3
DOIs	https://doi.org/10.1016/j.ceb.2008.03.019
State	Published - Jun 2008

Funding

I am grateful to Dr Edwin Smith for critical reading of this review and Laura Shilatifard for editorial assistance. The research in Shilatifard's Laboratory is supported by grants from the National Institutes of Health (2R01CA089455 and 1R01GM069905).

ASJC Scopus subject areas

Cell Biology

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10.1016/j.ceb.2008.03.019

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title = "Molecular implementation and physiological roles for histone H3 lysine 4 (H3K4) methylation",

abstract = "Chromosomal surfaces are ornamented with a variety of post-translational modifications of histones, which are required for the regulation of many of the DNA-templated processes. Such histone modifications include acetylation, sumoylation, phosphorylation, ubiquitination, and methylation. Histone modifications can either function by disrupting chromosomal contacts or by regulating non-histone protein interactions with chromatin. In this review, recent findings will be discussed regarding the regulation of the implementation and physiological significance for one such histone modification, histone H3 lysine 4 (H3K4) methylation by the yeast COMPASS and mammalian COMPASS-like complexes.",

author = "Ali Shilatifard",

note = "Funding Information: I am grateful to Dr Edwin Smith for critical reading of this review and Laura Shilatifard for editorial assistance. The research in Shilatifard's Laboratory is supported by grants from the National Institutes of Health (2R01CA089455 and 1R01GM069905). ",

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N1 - Funding Information: I am grateful to Dr Edwin Smith for critical reading of this review and Laura Shilatifard for editorial assistance. The research in Shilatifard's Laboratory is supported by grants from the National Institutes of Health (2R01CA089455 and 1R01GM069905).

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N2 - Chromosomal surfaces are ornamented with a variety of post-translational modifications of histones, which are required for the regulation of many of the DNA-templated processes. Such histone modifications include acetylation, sumoylation, phosphorylation, ubiquitination, and methylation. Histone modifications can either function by disrupting chromosomal contacts or by regulating non-histone protein interactions with chromatin. In this review, recent findings will be discussed regarding the regulation of the implementation and physiological significance for one such histone modification, histone H3 lysine 4 (H3K4) methylation by the yeast COMPASS and mammalian COMPASS-like complexes.

AB - Chromosomal surfaces are ornamented with a variety of post-translational modifications of histones, which are required for the regulation of many of the DNA-templated processes. Such histone modifications include acetylation, sumoylation, phosphorylation, ubiquitination, and methylation. Histone modifications can either function by disrupting chromosomal contacts or by regulating non-histone protein interactions with chromatin. In this review, recent findings will be discussed regarding the regulation of the implementation and physiological significance for one such histone modification, histone H3 lysine 4 (H3K4) methylation by the yeast COMPASS and mammalian COMPASS-like complexes.

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Molecular implementation and physiological roles for histone H3 lysine 4 (H3K4) methylation

Abstract

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