Molecular Landscape of Non-Muscle Invasive Bladder Cancer

Joshua J. Meeks, Seth P. Lerner*

*Corresponding author for this work

Research output: Contribution to journalShort surveypeer-review

8 Scopus citations

Abstract

In this issue of Cancer Cell, Hurst et al. report an integrated analysis of non-invasive (stage Ta) bladder cancer. Two genomic subtypes are distinguished by chromosome 9q loss, resulting in increased AKT/PI3K/mTOR signaling. Tumors from female patients have a higher frequency of KDM6A mutations. In this issue of Cancer Cell, Hurst et al. report an integrated analysis of non-invasive (stage Ta) bladder cancer. Two genomic subtypes are distinguished by chromosome 9q loss, resulting in increased AKT/PI3K/mTOR signaling and increased risk of recurrence. Tumors from female patients have a higher frequency of KDM6A mutations.

Original languageEnglish (US)
Pages (from-to)550-551
Number of pages2
JournalCancer Cell
Volume32
Issue number5
DOIs
StatePublished - Nov 13 2017

ASJC Scopus subject areas

  • Oncology
  • Cell Biology
  • Cancer Research

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