Molecular Landscape of Non-Muscle Invasive Bladder Cancer

Joshua J. Meeks; Seth P. Lerner

doi:10.1016/j.ccell.2017.08.015

Molecular Landscape of Non-Muscle Invasive Bladder Cancer

Joshua J. Meeks, Seth P. Lerner^*

^*Corresponding author for this work

Research output: Contribution to journal › Short survey › peer-review

8 Scopus citations

Abstract

In this issue of Cancer Cell, Hurst et al. report an integrated analysis of non-invasive (stage Ta) bladder cancer. Two genomic subtypes are distinguished by chromosome 9q loss, resulting in increased AKT/PI3K/mTOR signaling. Tumors from female patients have a higher frequency of KDM6A mutations. In this issue of Cancer Cell, Hurst et al. report an integrated analysis of non-invasive (stage Ta) bladder cancer. Two genomic subtypes are distinguished by chromosome 9q loss, resulting in increased AKT/PI3K/mTOR signaling and increased risk of recurrence. Tumors from female patients have a higher frequency of KDM6A mutations.

Original language	English (US)
Pages (from-to)	550-551
Number of pages	2
Journal	Cancer Cell
Volume	32
Issue number	5
DOIs	https://doi.org/10.1016/j.ccell.2017.08.015
State	Published - Nov 13 2017

ASJC Scopus subject areas

Oncology
Cell Biology
Cancer Research

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title = "Molecular Landscape of Non-Muscle Invasive Bladder Cancer",

abstract = "In this issue of Cancer Cell, Hurst et al. report an integrated analysis of non-invasive (stage Ta) bladder cancer. Two genomic subtypes are distinguished by chromosome 9q loss, resulting in increased AKT/PI3K/mTOR signaling. Tumors from female patients have a higher frequency of KDM6A mutations. In this issue of Cancer Cell, Hurst et al. report an integrated analysis of non-invasive (stage Ta) bladder cancer. Two genomic subtypes are distinguished by chromosome 9q loss, resulting in increased AKT/PI3K/mTOR signaling and increased risk of recurrence. Tumors from female patients have a higher frequency of KDM6A mutations.",

author = "Meeks, {Joshua J.} and Lerner, {Seth P.}",

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AB - In this issue of Cancer Cell, Hurst et al. report an integrated analysis of non-invasive (stage Ta) bladder cancer. Two genomic subtypes are distinguished by chromosome 9q loss, resulting in increased AKT/PI3K/mTOR signaling. Tumors from female patients have a higher frequency of KDM6A mutations. In this issue of Cancer Cell, Hurst et al. report an integrated analysis of non-invasive (stage Ta) bladder cancer. Two genomic subtypes are distinguished by chromosome 9q loss, resulting in increased AKT/PI3K/mTOR signaling and increased risk of recurrence. Tumors from female patients have a higher frequency of KDM6A mutations.

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JO - Cancer Cell

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Molecular Landscape of Non-Muscle Invasive Bladder Cancer

Abstract

ASJC Scopus subject areas

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