Molecular mechanisms of arrhythmogenic cardiomyopathy

Karyn M. Austin, Michael A. Trembley, Stephanie F. Chandler, Stephen P. Sanders, Jeffrey E. Saffitz, Dominic J. Abrams, William T. Pu*

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

105 Scopus citations


Arrhythmogenic cardiomyopathy is a genetic disorder characterized by the risk of life-threatening arrhythmias, myocardial dysfunction and fibrofatty replacement of myocardial tissue. Mutations in genes that encode components of desmosomes, the adhesive junctions that connect cardiomyocytes, are the predominant cause of arrhythmogenic cardiomyopathy and can be identified in about half of patients with the condition. However, the molecular mechanisms leading to myocardial destruction, remodelling and arrhythmic predisposition remain poorly understood. Through the development of animal, induced pluripotent stem cell and other models of disease, advances in our understanding of the pathogenic mechanisms of arrhythmogenic cardiomyopathy over the past decade have brought several signalling pathways into focus. These pathways include canonical and non-canonical WNT signalling, the Hippo–Yes-associated protein (YAP) pathway and transforming growth factor-β signalling. These studies have begun to identify potential therapeutic targets whose modulation has shown promise in preclinical models. In this Review, we summarize and discuss the reported molecular mechanisms underlying the pathogenesis of arrhythmogenic cardiomyopathy.

Original languageEnglish (US)
Pages (from-to)519-537
Number of pages19
JournalNature Reviews Cardiology
Issue number9
StatePublished - Sep 1 2019

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine


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