Abstract
Over the past decade, the Nomenclature Committee on Cell Death (NCCD) has formulated guidelines for the definition and interpretation of cell death from morphological, biochemical, and functional perspectives. Since the field continues to expand and novel mechanisms that orchestrate multiple cell death pathways are unveiled, we propose an updated classification of cell death subroutines focusing on mechanistic and essential (as opposed to correlative and dispensable) aspects of the process. As we provide molecularly oriented definitions of terms including intrinsic apoptosis, extrinsic apoptosis, mitochondrial permeability transition (MPT)-driven necrosis, necroptosis, ferroptosis, pyroptosis, parthanatos, entotic cell death, NETotic cell death, lysosome-dependent cell death, autophagy-dependent cell death, immunogenic cell death, cellular senescence, and mitotic catastrophe, we discuss the utility of neologisms that refer to highly specialized instances of these processes. The mission of the NCCD is to provide a widely accepted nomenclature on cell death in support of the continued development of the field.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 486-541 |
| Number of pages | 56 |
| Journal | Cell Death and Differentiation |
| Volume | 25 |
| Issue number | 3 |
| DOIs | |
| State | Published - Mar 1 2018 |
ASJC Scopus subject areas
- Molecular Biology
- Cell Biology
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Molecular mechanisms of cell death : Recommendations of the Nomenclature Committee on Cell Death 2018. / Galluzzi, Lorenzo; Vitale, Ilio; Aaronson, Stuart A.; Abrams, John M.; Adam, Dieter; Agostinis, Patrizia; Alnemri, Emad S.; Altucci, Lucia; Amelio, Ivano; Andrews, David W.; Annicchiarico-Petruzzelli, Margherita; Antonov, Alexey V.; Arama, Eli; Baehrecke, Eric H.; Barlev, Nickolai A.; Bazan, Nicolas G.; Bernassola, Francesca; Bertrand, Mathieu J.M.; Bianchi, Katiuscia; Blagosklonny, Mikhail V.; Blomgren, Klas; Borner, Christoph; Boya, Patricia; Brenner, Catherine; Campanella, Michelangelo; Candi, Eleonora; Carmona-Gutierrez, Didac; Cecconi, Francesco; Chan, Francis K.M.; Chandel, Navdeep S.; Cheng, Emily H.; Chipuk, Jerry E.; Cidlowski, John A.; Ciechanover, Aaron; Cohen, Gerald M.; Conrad, Marcus; Cubillos-Ruiz, Juan R.; Czabotar, Peter E.; D'Angiolella, Vincenzo; Dawson, Ted M.; Dawson, Valina L.; De Laurenzi, Vincenzo; De Maria, Ruggero; Debatin, Klaus Michael; Deberardinis, Ralph J.; Deshmukh, Mohanish; Di Daniele, Nicola; Di Virgilio, Francesco; Dixit, Vishva M.; Dixon, Scott J.; Duckett, Colin S.; Dynlacht, Brian D.; El-Deiry, Wafik S.; Elrod, John W.; Fimia, Gian Maria; Fulda, Simone; García-Sáez, Ana J.; Garg, Abhishek D.; Garrido, Carmen; Gavathiotis, Evripidis; Golstein, Pierre; Gottlieb, Eyal; Green, Douglas R.; Greene, Lloyd A.; Gronemeyer, Hinrich; Gross, Atan; Hajnoczky, Gyorgy; Hardwick, J. Marie; Harris, Isaac S.; Hengartner, Michael O.; Hetz, Claudio; Ichijo, Hidenori; Jäättelä, Marja; Joseph, Bertrand; Jost, Philipp J.; Juin, Philippe P.; Kaiser, William J.; Karin, Michael; Kaufmann, Thomas; Kepp, Oliver; Kimchi, Adi; Kitsis, Richard N.; Klionsky, Daniel J.; Knight, Richard A.; Kumar, Sharad; Lee, Sam W.; Lemasters, John J.; Levine, Beth; Linkermann, Andreas; Lipton, Stuart A.; Lockshin, Richard A.; López-Otín, Carlos; Lowe, Scott W.; Luedde, Tom; Lugli, Enrico; MacFarlane, Marion; Madeo, Frank; Malewicz, Michal; Malorni, Walter; Manic, Gwenola; Marine, Jean Christophe; Martin, Seamus J.; Martinou, Jean Claude; Medema, Jan Paul; Mehlen, Patrick; Meier, Pascal; Melino, Sonia; Miao, Edward A.; Molkentin, Jeffery D.; Moll, Ute M.; Muñoz-Pinedo, Cristina; Nagata, Shigekazu; Nuñez, Gabriel; Oberst, Andrew; Oren, Moshe; Overholtzer, Michael; Pagano, Michele; Panaretakis, Theocharis; Pasparakis, Manolis; Penninger, Josef M.; Pereira, David M.; Pervaiz, Shazib; Peter, Marcus E.; Piacentini, Mauro; Pinton, Paolo; Prehn, Jochen H.M.; Puthalakath, Hamsa; Rabinovich, Gabriel A.; Rehm, Markus; Rizzuto, Rosario; Rodrigues, Cecilia M.P.; Rubinsztein, David C.; Rudel, Thomas; Ryan, Kevin M.; Sayan, Emre; Scorrano, Luca; Shao, Feng; Shi, Yufang; Silke, John; Simon, Hans Uwe; Sistigu, Antonella; Stockwell, Brent R.; Strasser, Andreas; Szabadkai, Gyorgy; Tait, Stephen W.G.; Tang, Daolin; Tavernarakis, Nektarios; Thorburn, Andrew; Tsujimoto, Yoshihide; Turk, Boris; Vanden Berghe, Tom; Vandenabeele, Peter; Vander Heiden, Matthew G.; Villunger, Andreas; Virgin, Herbert W.; Vousden, Karen H.; Vucic, Domagoj; Wagner, Erwin F.; Walczak, Henning; Wallach, David; Wang, Ying; Wells, James A.; Wood, Will; Yuan, Junying; Zakeri, Zahra; Zhivotovsky, Boris; Zitvogel, Laurence; Melino, Gerry; Kroemer, Guido.
In: Cell Death and Differentiation, Vol. 25, No. 3, 01.03.2018, p. 486-541.Research output: Contribution to journal › Review article › peer-review
TY - JOUR
T1 - Molecular mechanisms of cell death
T2 - Recommendations of the Nomenclature Committee on Cell Death 2018
AU - Galluzzi, Lorenzo
AU - Vitale, Ilio
AU - Aaronson, Stuart A.
AU - Abrams, John M.
AU - Adam, Dieter
AU - Agostinis, Patrizia
AU - Alnemri, Emad S.
AU - Altucci, Lucia
AU - Amelio, Ivano
AU - Andrews, David W.
AU - Annicchiarico-Petruzzelli, Margherita
AU - Antonov, Alexey V.
AU - Arama, Eli
AU - Baehrecke, Eric H.
AU - Barlev, Nickolai A.
AU - Bazan, Nicolas G.
AU - Bernassola, Francesca
AU - Bertrand, Mathieu J.M.
AU - Bianchi, Katiuscia
AU - Blagosklonny, Mikhail V.
AU - Blomgren, Klas
AU - Borner, Christoph
AU - Boya, Patricia
AU - Brenner, Catherine
AU - Campanella, Michelangelo
AU - Candi, Eleonora
AU - Carmona-Gutierrez, Didac
AU - Cecconi, Francesco
AU - Chan, Francis K.M.
AU - Chandel, Navdeep S.
AU - Cheng, Emily H.
AU - Chipuk, Jerry E.
AU - Cidlowski, John A.
AU - Ciechanover, Aaron
AU - Cohen, Gerald M.
AU - Conrad, Marcus
AU - Cubillos-Ruiz, Juan R.
AU - Czabotar, Peter E.
AU - D'Angiolella, Vincenzo
AU - Dawson, Ted M.
AU - Dawson, Valina L.
AU - De Laurenzi, Vincenzo
AU - De Maria, Ruggero
AU - Debatin, Klaus Michael
AU - Deberardinis, Ralph J.
AU - Deshmukh, Mohanish
AU - Di Daniele, Nicola
AU - Di Virgilio, Francesco
AU - Dixit, Vishva M.
AU - Dixon, Scott J.
AU - Duckett, Colin S.
AU - Dynlacht, Brian D.
AU - El-Deiry, Wafik S.
AU - Elrod, John W.
AU - Fimia, Gian Maria
AU - Fulda, Simone
AU - García-Sáez, Ana J.
AU - Garg, Abhishek D.
AU - Garrido, Carmen
AU - Gavathiotis, Evripidis
AU - Golstein, Pierre
AU - Gottlieb, Eyal
AU - Green, Douglas R.
AU - Greene, Lloyd A.
AU - Gronemeyer, Hinrich
AU - Gross, Atan
AU - Hajnoczky, Gyorgy
AU - Hardwick, J. Marie
AU - Harris, Isaac S.
AU - Hengartner, Michael O.
AU - Hetz, Claudio
AU - Ichijo, Hidenori
AU - Jäättelä, Marja
AU - Joseph, Bertrand
AU - Jost, Philipp J.
AU - Juin, Philippe P.
AU - Kaiser, William J.
AU - Karin, Michael
AU - Kaufmann, Thomas
AU - Kepp, Oliver
AU - Kimchi, Adi
AU - Kitsis, Richard N.
AU - Klionsky, Daniel J.
AU - Knight, Richard A.
AU - Kumar, Sharad
AU - Lee, Sam W.
AU - Lemasters, John J.
AU - Levine, Beth
AU - Linkermann, Andreas
AU - Lipton, Stuart A.
AU - Lockshin, Richard A.
AU - López-Otín, Carlos
AU - Lowe, Scott W.
AU - Luedde, Tom
AU - Lugli, Enrico
AU - MacFarlane, Marion
AU - Madeo, Frank
AU - Malewicz, Michal
AU - Malorni, Walter
AU - Manic, Gwenola
AU - Marine, Jean Christophe
AU - Martin, Seamus J.
AU - Martinou, Jean Claude
AU - Medema, Jan Paul
AU - Mehlen, Patrick
AU - Meier, Pascal
AU - Melino, Sonia
AU - Miao, Edward A.
AU - Molkentin, Jeffery D.
AU - Moll, Ute M.
AU - Muñoz-Pinedo, Cristina
AU - Nagata, Shigekazu
AU - Nuñez, Gabriel
AU - Oberst, Andrew
AU - Oren, Moshe
AU - Overholtzer, Michael
AU - Pagano, Michele
AU - Panaretakis, Theocharis
AU - Pasparakis, Manolis
AU - Penninger, Josef M.
AU - Pereira, David M.
AU - Pervaiz, Shazib
AU - Peter, Marcus E.
AU - Piacentini, Mauro
AU - Pinton, Paolo
AU - Prehn, Jochen H.M.
AU - Puthalakath, Hamsa
AU - Rabinovich, Gabriel A.
AU - Rehm, Markus
AU - Rizzuto, Rosario
AU - Rodrigues, Cecilia M.P.
AU - Rubinsztein, David C.
AU - Rudel, Thomas
AU - Ryan, Kevin M.
AU - Sayan, Emre
AU - Scorrano, Luca
AU - Shao, Feng
AU - Shi, Yufang
AU - Silke, John
AU - Simon, Hans Uwe
AU - Sistigu, Antonella
AU - Stockwell, Brent R.
AU - Strasser, Andreas
AU - Szabadkai, Gyorgy
AU - Tait, Stephen W.G.
AU - Tang, Daolin
AU - Tavernarakis, Nektarios
AU - Thorburn, Andrew
AU - Tsujimoto, Yoshihide
AU - Turk, Boris
AU - Vanden Berghe, Tom
AU - Vandenabeele, Peter
AU - Vander Heiden, Matthew G.
AU - Villunger, Andreas
AU - Virgin, Herbert W.
AU - Vousden, Karen H.
AU - Vucic, Domagoj
AU - Wagner, Erwin F.
AU - Walczak, Henning
AU - Wallach, David
AU - Wang, Ying
AU - Wells, James A.
AU - Wood, Will
AU - Yuan, Junying
AU - Zakeri, Zahra
AU - Zhivotovsky, Boris
AU - Zitvogel, Laurence
AU - Melino, Gerry
AU - Kroemer, Guido
N1 - Funding Information: Acknowledgements We are indebted with Dr. Avi Ashkenazi (Gen-entech Inc.) for his constructive suggestions. We apologize to the authors of several high-quality articles dealing with mechanistic or pathophysiological aspects of cell death that we were not able to properly discuss. L.G. is supported by an intramural startup from the Department of Radiation Oncology of Weill Cornell Medical College (New York, US), and by Sotio a.c. (Prague, Czech Republic). I.V. is supported by the Associazione Italiana per la Ricerca sul Cancro (AIRC, IG 2017 grant number 20417), Ministero Italiano della Salute (grant number RF_GR-2011-02351355), Ministero Italiano dell’Is-truzione, dell’Università e della Ricerca (MIUR, Programma per i Giovani Ricercatori “Rita Levi Montalcini” 2010). G.K. is supported by the French Ligue contre le Cancer (équipe labellisée); Agence National de la Recherche (ANR)—Projets blancs; ANR under the frame of E-Rare-2, the ERA-Net for Research on Rare Diseases; Association pour la recherche sur le cancer (ARC); Cancéropôle Ile-de-France; Institut National du Cancer (INCa); Institut Universitaire de France; Fondation pour la Recherche Médicale (FRM); the European Commission (ArtForce); the European Research Council (ERC); the LeDucq Foundation; the LabEx Immuno-Oncology; the SIRIC Stratified Oncology Cell DNA Repair and Tumor Immune Elimination (SOCRATE); the SIRIC Cancer Research and Personalized Medicine (CARPEM); and the Paris Alliance of Cancer Research Institutes (PACRI). Funding Information: We are indebted with Dr. Avi Ashkenazi (Genentech Inc.) for his constructive suggestions. We apologize to the authors of several high-quality articles dealing with mechanistic or pathophysiological aspects of cell death that we were not able to properly discuss. L.G. is supported by an intramural startup from the Department of Radiation Oncology of Weill Cornell Medical College (New York, US), and by Sotio a.c. (Prague, Czech Republic). I.V. is supported by the Associazione Italiana per la Ricerca sul Cancro (AIRC, IG 2017 grant number 20417), Ministero Italiano della Salute (grant number RF-GR-2011-02351355), Ministero Italiano dell'Istruzione, dell'Universit? e della Ricerca (MIUR, Programma per i Giovani Ricercatori "Rita Levi Montalcini" 2010). G.K. is supported by the French Ligue contre le Cancer (?quipe labellis?e); Agence National de la Recherche (ANR)-Projets blancs; ANR under the frame of E-Rare-2, the ERA-Net for Research on Rare Diseases; Association pour la recherche sur le cancer (ARC); Canc?rop?le Ilede- France; Institut National du Cancer (INCa); Institut Universitaire de France; Fondation pour la Recherche M?dicale (FRM); the European Commission (ArtForce); the European Research Council (ERC); the LeDucq Foundation; the LabEx Immuno-Oncology; the SIRIC Stratified Oncology Cell DNA Repair and Tumor Immune Elimination (SOCRATE); the SIRIC Cancer Research and Personalized Medicine (CARPEM); and the Paris Alliance of Cancer Research Institutes (PACRI). Publisher Copyright: © 2018 ADMC Associazione Differenziamento e Morte Cellulare.
PY - 2018/3/1
Y1 - 2018/3/1
N2 - Over the past decade, the Nomenclature Committee on Cell Death (NCCD) has formulated guidelines for the definition and interpretation of cell death from morphological, biochemical, and functional perspectives. Since the field continues to expand and novel mechanisms that orchestrate multiple cell death pathways are unveiled, we propose an updated classification of cell death subroutines focusing on mechanistic and essential (as opposed to correlative and dispensable) aspects of the process. As we provide molecularly oriented definitions of terms including intrinsic apoptosis, extrinsic apoptosis, mitochondrial permeability transition (MPT)-driven necrosis, necroptosis, ferroptosis, pyroptosis, parthanatos, entotic cell death, NETotic cell death, lysosome-dependent cell death, autophagy-dependent cell death, immunogenic cell death, cellular senescence, and mitotic catastrophe, we discuss the utility of neologisms that refer to highly specialized instances of these processes. The mission of the NCCD is to provide a widely accepted nomenclature on cell death in support of the continued development of the field.
AB - Over the past decade, the Nomenclature Committee on Cell Death (NCCD) has formulated guidelines for the definition and interpretation of cell death from morphological, biochemical, and functional perspectives. Since the field continues to expand and novel mechanisms that orchestrate multiple cell death pathways are unveiled, we propose an updated classification of cell death subroutines focusing on mechanistic and essential (as opposed to correlative and dispensable) aspects of the process. As we provide molecularly oriented definitions of terms including intrinsic apoptosis, extrinsic apoptosis, mitochondrial permeability transition (MPT)-driven necrosis, necroptosis, ferroptosis, pyroptosis, parthanatos, entotic cell death, NETotic cell death, lysosome-dependent cell death, autophagy-dependent cell death, immunogenic cell death, cellular senescence, and mitotic catastrophe, we discuss the utility of neologisms that refer to highly specialized instances of these processes. The mission of the NCCD is to provide a widely accepted nomenclature on cell death in support of the continued development of the field.
UR - http://www.scopus.com/inward/record.url?scp=85036533976&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85036533976&partnerID=8YFLogxK
U2 - 10.1038/s41418-017-0012-4
DO - 10.1038/s41418-017-0012-4
M3 - Review article
C2 - 29362479
AN - SCOPUS:85036533976
VL - 25
SP - 486
EP - 541
JO - Cell Death and Differentiation
JF - Cell Death and Differentiation
SN - 1350-9047
IS - 3
ER -