Molecular mechanisms of host cell invasion by Trypanosoma cruzi

Conrad L. Epting*, Bria M. Coates, David M. Engman

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

71 Scopus citations


The protozoan parasite Trypanosoma cruzi, the etiologic agent of Chagas disease, is an obligate intracellular protozoan pathogen. Overlapping mechanisms ensure successful infection, yet the relationship between these cellular events and clinical disease remains obscure. This review explores the process of cell invasion from the perspective of cell surface interactions, intracellular signaling, modulation of the host cytoskeleton and endosomal compartment, and the intracellular innate immune response to infection.

Original languageEnglish (US)
Pages (from-to)283-291
Number of pages9
JournalExperimental Parasitology
Issue number3
StatePublished - Nov 2010


  • Invasion
  • Lysosome
  • Microtubules
  • Signaling
  • Trypanosoma cruzi

ASJC Scopus subject areas

  • Infectious Diseases
  • Parasitology
  • Immunology


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