Molecular mechanisms of host cell invasion by Trypanosoma cruzi

Conrad L. Epting*, Bria M. Coates, David M. Engman

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

60 Scopus citations

Abstract

The protozoan parasite Trypanosoma cruzi, the etiologic agent of Chagas disease, is an obligate intracellular protozoan pathogen. Overlapping mechanisms ensure successful infection, yet the relationship between these cellular events and clinical disease remains obscure. This review explores the process of cell invasion from the perspective of cell surface interactions, intracellular signaling, modulation of the host cytoskeleton and endosomal compartment, and the intracellular innate immune response to infection.

Original languageEnglish (US)
Pages (from-to)283-291
Number of pages9
JournalExperimental Parasitology
Volume126
Issue number3
DOIs
StatePublished - Nov 2010

Keywords

  • Invasion
  • Lysosome
  • Microtubules
  • Signaling
  • Trypanosoma cruzi

ASJC Scopus subject areas

  • Parasitology
  • Immunology
  • Infectious Diseases

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