Molecular mechanisms of sleep homeostasis in flies and mammals

Ravi Allada*, Chiara Cirelli, Amita Sehgal

*Corresponding author for this work

Research output: Contribution to journalArticle

42 Scopus citations

Abstract

Sleep is homeostatically regulated with sleep pressure accumulating with the increasing duration of prior wakefulness. Yet, a clear understanding of the molecular components of the homeostat, as well as the molecular and cellular processes they sense and control to regulate sleep intensity and duration, remain a mystery. Here,we will discuss the cellular and molecular basis of sleep homeostasis, first focusing on the best homeostatic sleep marker in vertebrates, slow wave activity; second, moving to the molecular genetic analysis of sleep homeostasis in the fruit fly Drosophila; and, finally, discussing more systemic aspects of sleep homeostasis.

Original languageEnglish (US)
Article numbera027730
JournalCold Spring Harbor Perspectives in Biology
Volume9
Issue number8
DOIs
StatePublished - 2017

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

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