Molecular mechanisms underlying cellular effects of human MEK1 mutations

Keyphrases

• Human Disease 100%
• ERK Activation 100%
• Molecular Mechanism 100%
• Drosophila Embryo 100%
• Extracellular Signaling 100%
• Cellular Effects 100%
• MEK1 mutations 100%
• Adaptor 50%
• Kinase Activity 50%
• Attenuation 50%
• Disease-causing mutations 50%
• Dephosphorylation 50%
• Terminal Region 50%
• Pathogenic Variants 50%
• MEK1 50%
• Independent Activity 50%
• Multisite Phosphorylation 50%
• Multiple Persons 50%
• Gain-of-function Variant 50%
• Negative Feedback 50%
• Alanine Substitution 50%
• Signal-dependent 50%
• Activation Loop 50%
• Mutant Variants 50%
• DUSP1 50%
• MEK Kinase 50%
• Negative Regulatory Region 50%
• Terminal Patterning 50%
• Kinase Suppressor of Ras 50%

Biochemistry, Genetics and Molecular Biology

• Kinase 100%
• Phosphotransferase 100%
• Product Inhibition 33%
• Dephosphorylation 33%
• Regulatory Region 33%
• Dual-Specificity Phosphatase 33%
• Alanine 33%