TY - JOUR
T1 - Molecular prognostic factors for breast cancer metastasis and survival
AU - Esteva, Francisco J.
AU - Sahin, Aysegul A.
AU - Cristofanilli, Massimo
AU - Arun, Banu
AU - Hortobagyi, Gabriel N.
PY - 2002/10
Y1 - 2002/10
N2 - The biological characteristics of the tumor are used to estimate prognosis and select appropriate systemic therapy for patients with early-stage breast cancer. Well-established molecular prognostic factors include the estrogen and progesterone receptors, proliferation markers, and the HER2 gene. Novel tumor markers with potential clinical utility include molecules involved in cell transformation, invasion, and metastases. We review the available data supporting the utility of established prognostic and predictive molecular factors, and discuss challenges for integrating novel molecular markers into clinical practice.
AB - The biological characteristics of the tumor are used to estimate prognosis and select appropriate systemic therapy for patients with early-stage breast cancer. Well-established molecular prognostic factors include the estrogen and progesterone receptors, proliferation markers, and the HER2 gene. Novel tumor markers with potential clinical utility include molecules involved in cell transformation, invasion, and metastases. We review the available data supporting the utility of established prognostic and predictive molecular factors, and discuss challenges for integrating novel molecular markers into clinical practice.
UR - http://www.scopus.com/inward/record.url?scp=0036798273&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0036798273&partnerID=8YFLogxK
U2 - 10.1053/srao.2002.35251
DO - 10.1053/srao.2002.35251
M3 - Article
C2 - 12382190
AN - SCOPUS:0036798273
VL - 12
SP - 319
EP - 328
JO - Seminars in Radiation Oncology
JF - Seminars in Radiation Oncology
SN - 1053-4296
IS - 4
ER -
