TY - JOUR
T1 - Molecular properties of the CRF receptor
AU - Spiess, Joachim
AU - Dautzenberg, Frank M.
AU - Sydow, Sabine
AU - Hauger, Richard L.
AU - Rühmann, Andreas
AU - Blank, Thomas
AU - Radulovic, Jelena
PY - 1998/12/1
Y1 - 1998/12/1
N2 - Research into the biology of corticotropin-releasing factor (CRF) has been intensified significantly by the structural characterization of the CRF receptor (CRF-R). Two receptor subtypes, CRF-R1 and CRF-R2, and three functional splice variants of CRF-R2 have been discovered. It appears that ligand binding requires interaction of the N-terminal domain with one or two other extracellular domains of the CRF-R. In contrast to the mammalian CRF- R1, the frog CRF-R1 discriminates between naturally occurring CRF-like peptides.
AB - Research into the biology of corticotropin-releasing factor (CRF) has been intensified significantly by the structural characterization of the CRF receptor (CRF-R). Two receptor subtypes, CRF-R1 and CRF-R2, and three functional splice variants of CRF-R2 have been discovered. It appears that ligand binding requires interaction of the N-terminal domain with one or two other extracellular domains of the CRF-R. In contrast to the mammalian CRF- R1, the frog CRF-R1 discriminates between naturally occurring CRF-like peptides.
UR - http://www.scopus.com/inward/record.url?scp=0031778124&partnerID=8YFLogxK
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U2 - 10.1016/S1043-2760(98)00037-X
DO - 10.1016/S1043-2760(98)00037-X
M3 - Review article
C2 - 18406257
AN - SCOPUS:0031778124
SN - 1043-2760
VL - 9
SP - 140
EP - 145
JO - Trends in Endocrinology and Metabolism
JF - Trends in Endocrinology and Metabolism
IS - 4
ER -
