Molecular properties of the CRF receptor

Joachim Spiess*, Frank M. Dautzenberg, Sabine Sydow, Richard L. Hauger, Andreas Rühmann, Thomas Blank, Jelena Radulovic

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

41 Scopus citations


Research into the biology of corticotropin-releasing factor (CRF) has been intensified significantly by the structural characterization of the CRF receptor (CRF-R). Two receptor subtypes, CRF-R1 and CRF-R2, and three functional splice variants of CRF-R2 have been discovered. It appears that ligand binding requires interaction of the N-terminal domain with one or two other extracellular domains of the CRF-R. In contrast to the mammalian CRF- R1, the frog CRF-R1 discriminates between naturally occurring CRF-like peptides.

Original languageEnglish (US)
Pages (from-to)140-145
Number of pages6
JournalTrends in Endocrinology and Metabolism
Issue number4
StatePublished - Dec 1 1998

ASJC Scopus subject areas

  • Endocrinology
  • Endocrinology, Diabetes and Metabolism


Dive into the research topics of 'Molecular properties of the CRF receptor'. Together they form a unique fingerprint.

Cite this