Molecularly confirmed primary prostatic synovial sarcoma

Michael Fritsch, Jonathan I. Epstein, Elizabeth J. Perlman, John C. Watts, Pedram Argani*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

15 Scopus citations

Abstract

We report the second molecularly-confirmed primary prostatic synovial sarcoma. The diagnosis was particularly elusive at the light microscopic level in that the tumor failed to show epithelial differentiation, but it did show combined spindle-cell and poorly differentiated (round-cell) morphologies. The immunohistochemical staining profile was nonspecific and potentially misleading. Only by demonstration of the characteristic SYT-SSX gene fusion of synovial sarcoma by reverse transcriptase polymerase chain reaction (RT-PCR) analysis of RNA extracted from archival material could the diagnosis be confirmed. This case further illustrates the use of this technique in diagnostic pathology. (C) 2000 W.B. Saunders Company.

Original languageEnglish (US)
Pages (from-to)246-250
Number of pages5
JournalHuman Pathology
Volume31
Issue number2
DOIs
StatePublished - Jan 1 2000

Keywords

  • Prostate
  • Reverse transcriptase polymerase chain reaction
  • Synovial sarcoma

ASJC Scopus subject areas

  • Pathology and Forensic Medicine

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