Mometasone furoate sinus implant–a new targeted approach to treating recurrent nasal polyp disease

Jasper Shen*, Kevin Welch, Robert Kern

*Corresponding author for this work

Research output: Contribution to journalArticle

1 Scopus citations

Abstract

Introduction: Chronic rhinosinusitis (CRS) is a broad heterogeneous inflammatory disorder of the nose and paranasal sinuses, resulting from the dysfunctional interplay between host immunity, defective epithelial barrier, and environmental factors. CRS with nasal polyps (CRSwNP) is considered a more severe clinical phenotype with greater burden of symptoms and higher relapse rate, especially with comorbid asthma or aspirin sensitivity. Available treatment options after endoscopic sinus surgery (ESS)–systemic corticosteroids or revision surgery–have significant risks and limitations. Areas covered: Bioabsorbable, steroid-eluting implants have been studied extensively for the ability to dilate and re-establish sinus patency by the localized, controlled delivery of topical corticosteroids to diseased sinonasal lining and nasal polyps. This review provides a comprehensive, up to date analysis of the literature regarding a novel, office-based, mometasone furoate (MF) sinus implant that may treat patients with recurrent CRSwNP after ESS. Expert commentary: Clinical evidence has demonstrated the safety and efficacy of steroid-eluting implant in the reduction of polyp size, symptom burden, and the need for revision sinus surgery. MF sinus implants may play an important role in the management of patients with recurrent polyposis after sinus surgery.

Original languageEnglish (US)
Pages (from-to)1163-1170
Number of pages8
JournalExpert Review of Clinical Pharmacology
Volume11
Issue number12
DOIs
StatePublished - Dec 2 2018

Keywords

  • Chronic rhinosinusitis
  • SINUVA
  • endoscopic sinus surgery
  • mometasone furoate
  • nasal polyps
  • sinus implant

ASJC Scopus subject areas

  • Pharmacology, Toxicology and Pharmaceutics(all)
  • Pharmacology (medical)

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