Monitoring Canine Myocardial Infarction Formation and Recovery via Transthoracic Cardiac Strain Imaging

Vincent Sayseng, Rebecca A. Ober, Christopher S. Grubb, Rachel A. Weber, Elisa Konofagou*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

6 Scopus citations


Myocardial elastography (ME) is an ultrasound-based strain imaging method that aims to determine the degree of ischemia or infarction as a result of the change in the elastic properties of the myocardium. A survival canine model (n = 11) was employed to investigate the ability of ME to image myocardial infarction formation and recovery. Infarcts were generated by ligation of the left anterior descending coronary artery. Canines were survived and imaged for 4 days (n = 7) or 4 weeks (n = 4), allowing sufficient time for recovery via collateral perfusion. A radial strain-based metric, percentage of healthy myocardium by strain (PHMε), was developed as a marker for healthy myocardial tissue. PHMε was strongly linearly correlated with actual infarct size as determined by gross pathology (R2 = 0.80). Mean PHMε was reduced 1–3 days post-infarction (p < 0.05) at the papillary and apical short-axis levels; full infarct recovery was achieved by day 28, with mean PHMε returning to baseline levels. ME was capable of diagnosing individual myocardial segments as non-infarcted or infarcted with high sensitivity (82%), specificity (92%) and precision (85%) (area under the receiver operating characteristic curve = 0.90). The study therefore strengthens the ME premise that it can detect and assess myocardial infarction progression and recovery in vivo and could thus provide an important role in both disease diagnosis and treatment assesssment.

Original languageEnglish (US)
Pages (from-to)2785-2800
Number of pages16
JournalUltrasound in Medicine and Biology
Issue number10
StatePublished - Oct 2020


  • Acute myocardial infarction
  • Animal model
  • Strain imaging
  • Transthoracic echocardiography

ASJC Scopus subject areas

  • Radiological and Ultrasound Technology
  • Biophysics
  • Acoustics and Ultrasonics


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